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New amino sugar analogues are incorporated at different rates into glycoproteins of mouse organs

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Abstract

Different radiolabelled N-acyl-derivatives of D-glucosamine were synthesized using D-glucosamine and the respective carbonic acid anhydride. Metabolism of these sugar analogues could be shown in vitro as well as in vivo. After the intraperitoneal administration of these radiolabelled N-acyl-D-glucosamines to mice, their rate of incorporation into glycoproteins of different organs was found to increase markedly with the length of the N-acyl side chain. Highest incorporation was measured in the whole intestine using N-pentanoyl-D-glucosamine as label.

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Authors and Affiliations

  1. Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Arnimallee 22, D-14195, Berlin, (Dahlem), (Germany)

    H. Kayser & W. Reutter

  2. Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität Freiburg, Albertstr. 21, D-79104, Freiburg, (Germany)

    C. Ats & J. Lehmann

Authors
  1. H. Kayser
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  2. C. Ats
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  3. J. Lehmann
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  4. W. Reutter
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Kayser, H., Ats, C., Lehmann, J. et al. New amino sugar analogues are incorporated at different rates into glycoproteins of mouse organs. Experientia 49, 885–887 (1993). https://doi.org/10.1007/BF01952603

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  • DOI: https://doi.org/10.1007/BF01952603

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