Summary
The structure of the cytotoxic sesquiterpene lactone, stizolicin, reisolated fromStizolophus balsamitus (Centaurea b.) was revised to atrans, trans germacranolide (1) on the basis of simultaneous application of lanthanide shift reagent and NOE in the NMR.
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References
Epigeal portions collected in June 1978 from Karaj, 40 km west of Tehran, Iran, and shade dried.A voucher specimen (No. 86) is on deposit in the herbarium of the Department of Pharmacognosy, University of Tehran, asCentaurea balsamita Lam.
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The authors acknowledge the use of the Purdue University Biomedical Magnetic Resonance Laboratory (NIH grant No. RR01077). Support of contract No. N01-CM-97296 and Grant No. CA-33326 from the National Cancer Institute, HHS is gratefully acknowledged. This is paper 18 in the series ‘Potential Antitumor Agents’.
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Cassady, J.M., Bean, M.F., McLaughlin, J.L. et al. Structure revision and cytotoxicity of the germacranolide, stizolicin, fromStizolophus balsamitus (Asteraceae). Experientia 40, 930–931 (1984). https://doi.org/10.1007/BF01946442
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DOI: https://doi.org/10.1007/BF01946442