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Effects of rubratoxin B on prenatal development in mice

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Summary

Single doses (0.4, 0.6, 0.9, or 1.2 mg/kg) of rubratoxin B were given ip to albino mice on days 6–12 of gestation and fetuses were examined on day 18. Results indicated that rubratoxin is a growth retardant, a potent embryocide and a teratogen. Exencephaly, malformed pinnae, malformed jaws, umbilical hernia and open eye were the most commonly noted developmental anomalies associated with rubratoxin treatment.

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Authors and Affiliations

  1. Departments of Biology and Microbiology, The University of Alabama, 35486, University, Ala.

    Ronald D. Hood, Janice E. Innes & A. Wallace Hayes

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  1. Ronald D. Hood
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  2. Janice E. Innes
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  3. A. Wallace Hayes
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Hood, R.D., Innes, J.E. & Hayes, A.W. Effects of rubratoxin B on prenatal development in mice. Bull. Environ. Contam. Toxicol. 10, 200–207 (1973). https://doi.org/10.1007/BF01684545

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  • DOI: https://doi.org/10.1007/BF01684545

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