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H-2-Mediated resistance to an ecotropic type C retrovirus: Localization of controlling genes and ontogenic studies of resistance

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Abstract

H-2 recombinant mice of the C57BL/10 series were used to study resistance to infection by an ecotropic (B-tropic) type C retrovirus. The gene(s) responsible for resistance was mapped to theI- E/I-C subregions. Ontogenic studies indicated that thisI-region mediated resistance is not present in the neonate but develops with age, and is firmly established within 2 weeks after birth. This temporary neonatal susceptibility in mice of resistant genotype is not the result of active suppression of the immune response.

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Author notes

  1. Philip N. Tsichlis

    Present address: Laboratory of Tumor Virus Genetics, National Cancer Institute, NIH, 20014, Bethesda, Maryland

Authors and Affiliations

  1. Cancer Research Center, Tufts University School of Medicine, 136 Harrison Avenue, 02111, Boston, Massachusetts

    Susan E. Bear, Philip N. Tsichlis & Robert S. Schwanz

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  1. Susan E. Bear
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Bear, S.E., Tsichlis, P.N. & Schwanz, R.S. H-2-Mediated resistance to an ecotropic type C retrovirus: Localization of controlling genes and ontogenic studies of resistance. Immunogenetics 11, 451–465 (1980). https://doi.org/10.1007/BF01567814

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  • DOI: https://doi.org/10.1007/BF01567814

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