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Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse

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Somatic Cell and Molecular Genetics

Abstract

The genes encoding the two plasminogen activators, tissue plasminogen activator and urokinase, were mapped to mouse chromosomes using probes derived from the respective mouse cDNAs. DNA from mouse-Chinese hamster and mouse-rat somatic cell hybrids was digested with BamHI and EcoRI, respectively, and analyzed by Southern blot hybridization for the segregation of the two genes. Tissue plasminogen activator and urokinase cosegregated with mouse chromosomes 8 and 14, respectively. The plasminogen activator genes thus fall into two syntenic groups that are conserved in human and mouse.

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Authors and Affiliations

  1. Friedrich Miescher-Institut, P.O. Box 2543, CH-4002, Basel, Switzerland

    Bhanu Rajput

  2. University of Texas Health Science Center, San Antonio, Texas

    Angus Marshall, Ann M. Killary & Susan L. Naylor

  3. Institute for Medical Research, Bennington, Vermont

    Peter A. Lalley

  4. Départment de Pathologie, Center Médical Universitaire, Geneva, Switzerland

    Dominique Belin

  5. Department of Pharmacology, State University of New York at Stony Brook, 11794, Stony Brook, New York

    Richard J. Rickles & Sidney Strickland

Authors
  1. Bhanu Rajput
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  2. Angus Marshall
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  3. Ann M. Killary
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  4. Peter A. Lalley
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  5. Susan L. Naylor
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  6. Dominique Belin
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  7. Richard J. Rickles
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  8. Sidney Strickland
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Rajput, B., Marshall, A., Killary, A.M. et al. Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. Somat Cell Mol Genet 13, 581–586 (1987). https://doi.org/10.1007/BF01534500

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  • DOI: https://doi.org/10.1007/BF01534500

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