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Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

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Somatic Cell and Molecular Genetics

Abstract

The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

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Authors and Affiliations

  1. Institute for Molecular Genetics, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, Texas

    Jeffrey S. Chamberlain, Alice A. Reeves & C. Thomas Caskey

  2. New York State Department of Health, Roswell Park Memorial Institute, 14263, Buffalo, New York

    Stephen G. Grant, Linda J. Mullins, Dennis A. Stephenson & Verne M. Chapman

  3. Division of Genetics, Department of Pediatrics, Harvard Medical School Children's Hospital, 02115, Boston, Massachusetts

    Eric P. Hoffman, Anthony P. Monaco & Louis M. Kunkel

  4. The Program in Neuroscience, Harvard University, 02138, Cambridge, Massachusetts

    Eric P. Hoffman, Anthony P. Monaco & Louis M. Kunkel

Authors
  1. Jeffrey S. Chamberlain
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  2. Stephen G. Grant
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  3. Alice A. Reeves
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  4. Linda J. Mullins
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  5. Dennis A. Stephenson
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  6. Eric P. Hoffman
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  7. Anthony P. Monaco
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  8. Louis M. Kunkel
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  9. C. Thomas Caskey
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  10. Verne M. Chapman
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Chamberlain, J.S., Grant, S.G., Reeves, A.A. et al. Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome. Somat Cell Mol Genet 13, 671–678 (1987). https://doi.org/10.1007/BF01534487

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  • DOI: https://doi.org/10.1007/BF01534487

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