Abstract
The process of action potential production is analyzed in relation to the problem of energy transduction in the nerve. Describing the conditions required for the maintenance of excitability, the indispensability of divalent cations and the dispensability of univalent cations in the external medium are emphasized. Univalent cations with a strong tendency toward hydration enhance the action potential amplitude when added to the external Ca-salt solution. Experimental facts are described in consonance with the macromolecular interpretation of nerve excitation which postulates a transition of the negatively charged membrane macromolecules from a hydrophobic (resting) state to a hydrophilic (excited) state. Thermodynamic implications are discussed in relation to changes in enthalpy and volume accompanied by action potential production. Difficulties associated with analyses of excitation processes on a molecular basis are stressed.
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References
A. L. Hodgkin and B. Katz,J. Physiol.,108 (1949) 37.
E. Overton,Pflügers Arch. f. ges. Physiol.,92 (1902) 346.
R. Lorente de No, F. Vidal and L. M. H. Larramendi,Nature,179 (1957) 737.
B. Hille,Proc. Nat. Acad. Sci.,68 (1971) 280.
I. Tasaki, I. Singer and A. Watanabe,Amer. J. Physiol.,211 (1966) 746.
I. Tasaki,Nerve Excitation, A Macromolecular Approach, Charles C. Thomas, Springfield, Illinois, 1968.
I. Tasaki, A. Watanabe and L. Lerman,Amer. J. Physiol. 213 (1967) 1465.
A. Watanabe, I. Tasaki and L. Lerman,Proc. Nat. Acad. Sci.,58 (1967) 2246.
I. Tasaki, L. Lerman and A. Watanabe,Amer. J. Physiol.,216 (1969) 130.
I. Tasaki, I. Singer and T. Takenaka,J. Gen. Physiol.,48 (1965) 1095.
K. S. Cole and H. J. Curtis,J. Gen. Physiol.,22 (1939) 649.
R. D. Keynes,J. Physiol.,114 (1951) 119.
A. L. Hodgkin and R. D. Keynes,J. Physiol.,119 (1953) 513.
O. Kedem and A. Essig,J. Gen. Physiol.,48 (1965) 1047.
I. Tasaki, I. Singer, and A. Watanabe,J. Gen. Physiol.,50 (1967) 988.
A. L. Hodgkin and R. D. Keynes,J. Physiol.,138 (1957) 253.
T. Teorell,Progr. Biophys.,3 (1953) 305.
K. Sollner,J. Macromol. Sci. Chem.,A3 (1969) 1.
J. A. Kitchner, in:Modern Aspects of Electrochemistry, J. O. Brockris (ed.), Vol. II, Academic Press, New York, 1959, p. 87.
L. Mullins,J. Gen. Physiol.,43 (1960) 105.
P. F. Baker,Sci. Amer.,214 (1966) 74.
A. L. Hodgkin and A. F. Huxley,J. Physiol.,117 (1952) 500.
F. Helfferich,Ion Exchange, McGraw-Hill, New York, 1962.
A. Ikegami and N. Imai,J. Polymer Sci.,56 (1962) 133.
O. Smidsrod and A. Haug,J. Polymer Sci. C,16 (1967) 1587.
E. Matijevic, J. Leja and R. Nemeth,J. Colloid and Interface Sci.,22 (1966) 419.
R. M. Barrer and J. D. Falconer,Proc. Roy. Soc. A,236 (1956) 227.
D. H. Olson and H. S. Sherry,J. Phys. Chem.,72, (1968) 4095.
I. Tasaki, A. Watanabe and M. Hallett,Proc. Nat. Acad. Sci.,68 (1971) 938.
I. Tasaki, T. Takenaka and S. Yamagishi,Amer. J. Physiol. 215 (1968) 152.
W. J. V. Osterhout and S. E. Hill,J. Gen. Physiol.,22 (1938) 139.
F. T. Wall and J. W. Drenan,J. Polymer Sci.,7 (1951) 83.
N. T. Coleman,Soil Sci.,74 (1952) 115.
R. M. Barrer, L. V. C. Rees and D. J. Ward,Proc. Roy. Soc. A,273 (1963) 180.
H. S. Sherry and H. F. Walton,J. Phys. Chem.,71 (1967) 1457.
B. C. Abbott, A. V. Hill and J. V. Howarth,Proc. Roy. Soc. B,148 (1958) 149.
J. V. Howarth, R. D. Keynes and J. M. Richie,J. Physiol.,194 (1968) 745.
J. W. Moore, T. Narahashi and T. I. Shaw,J. Physiol.,188 (1967) 99.
C. S. Spyropoulos,Amer. J. Physiol.,200 (1961) 2064.
F. Oosawa,Polyelectrolytes Marcel Dekker, Inc., New York, 1971.
C. S. Spyropoulos,J. Gen. Physiol.,40 (1957) 849.
C. S. Spyropoulos and E. M. Ezzy,Amer. J. Physiol.,197 (1959) 808.
F. Conti and G. Palmieri,Biophysik,5 (1968) 71.
E. A. GuggenheimThermodynamics, 3rd Ed., Interscience, New York, 1957.
A. Essig,Biophys. J.,8 (1968) 53.
P. F. Baker, M. P. Blaustein, A. L. Hodgkin and R. A. Steinhardt,J. Physiol.,200 (1969) 431.
P. C. Caldwell,J. Physiol.,152 (1960) 545.
F. J. Brinley and L. J. Mullins,J. Gen. Physiol.,52 (1968) 181.
S. I. Rapoport,Biophys. J.,11 (1971) 631.
M. P. Blaustein and A. L. Hodgkin,J. Physiol.,200 (1969) 497.
C. M. Connelly,Biol. Bull.,103 (1952) 315.
M. G. Doane,J. Gen. Physiol.,50 (1967) 2603.
P. F. Baker,J. Physiol.,180 (1965) 383.
J. M. Richie,J. Physiol.,188 (1967) 309.
M. G. Larrabee,Progr. in Brain Res.,31 (1969) 95.
E. Giacobini,Protoplasma,63 (1967) 52.
L. A. Cuervo and W. J. Adelman,J. Gen. Physiol.,55 (1970) 309.
H. N. Fishman,Biophys. J.,10 (1970) 799.
L. B. Cohen and R. D. Keynes,J. Physiol. 212 (1971) 259.
L. B. Cohen, B. Hille and R. D. Keynes,J. Physiol.,211 (1970) 495.
P. Mueller and D. O. Rudin,J. Theor. Biol.,18 (1968) 222.
G. Ehrenstein, H. Lecar and R. Nossal,J. Gen. Physiol. 55 (1970) 119.
D. E. Goldman,Biophys. J.,4 (1964) 167.
L. Bass and W. J. Moore, in:Structural Chemistry and Molecular Biology, A. Rich and N. Davidson (eds.), W. H. Freeman and Co., San Francisco, 1968, p. 356.
G. Adam,Z. Naturforsch.,23b (1968) 181.
J. H. Wang,Proc. Nat. Acad. Sci.,67 (1970) 916.
L. Y. Wei,Math. Biophys.,33 (1971) 187.
T. L. Hill and Y.-D. Chen,Proc. Nat. Acad. Sci.,68 (1971) 1711.
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Tasaki, I., Hallett, M. Bioenergetics of nerve excitation. J Bioenerg Biomembr 3, 65–79 (1972). https://doi.org/10.1007/BF01515998
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DOI: https://doi.org/10.1007/BF01515998