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Evidence for the propagation of the virus of serum hepatitis in the chick embryo

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Summary

Evidence has been presented which indicates that the virus of serum hepatitis (SH) has been carried through 15 passages in the amniotic cavity of the chick embryo. 1. Intramuscular injection of amniotic fluid of the 9th and 15th passage into volunteers induced hepatitis without jaundice in 4 out of 6 and 2 out of 5 individuals, respectively, after incubation periods in excess of 60 days. 2. Serum taken from one of the patients in the first group during the acute stage of illness, when given to additional 4 volunteers resulted in 3 cases of hepatitis with, and one without jaundice.

Challenge of the volunteers of the 1st group with natural virus (icterogenic serum) 8 months after the primary injection led to a second attack of hepatitis in 2 of the individuals. One of these was the donor of the serum referred to under 2. Possible reasons for the absence of solid immunity after the 1st exposure have been discussed.

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References

  1. Colbert, J. W. Jr: Yale J. Biol. a. Med. (Am.)21, 335 (1949).

    Google Scholar 

  2. Henle, W., S. Harris, G. Henle, T. N. Harris, M. E. Drake, F. Mangold andJ. Stokes, Jr.: J. exper. Med. (Am.)92, 271 (1950).

    Article  CAS  Google Scholar 

  3. Drake, M. E., A. W. Kitts, M. C. Blanchard, J. D. Farquhar, J. Stokes, Jr. andW. Henle: J. exper. Med. (Am.)92, 283 (1950).

    Article  CAS  Google Scholar 

  4. Neefe, J. R., J. Stokes, Jr. andS. S. Gellis: Amer. J. med. Sci.210, 561 (1945).

    Article  Google Scholar 

  5. Unpublished observations.

  6. Henle, G., M. E. Drake, W. Henle andJ. Stokes, Jr.: Proc. Soc. exper. Biol. a. Med.73, 603 (1950).

    Article  CAS  Google Scholar 

  7. Drake, M. E., J. Stokes, Jr.,W. Henle, R. B. Pennell, J. Spizizen andB. Hampil: To be published.

  8. Neefe, J. R., S. S. Gellis andJ. Stokes, Jr.: Amer. J. med.1, 3 (1946).

    Article  CAS  PubMed  Google Scholar 

  9. Unpublished observations.

  10. Berk, J. E., L. L. Malamut, J. Stokes, Jr. andM. E. Drake.

  11. Drake,M. E., J. Stokes, Jr.,J. E. Berk andL. L. Malamut: To be published.

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Authors and Affiliations

  1. The Children's Hospital of Philadelphia, the Division of Virology, Department of Public Health and Preventive Medicine and the Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

    Werner Henle, Miles E. Drake, Gertrude Henle & Joseph Stokes Jr.

Authors
  1. Werner Henle
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  2. Miles E. Drake
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  3. Gertrude Henle
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  4. Joseph Stokes Jr.
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Dedicated to Prof. Dr.R. Doerr on this 80th birthday.

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Henle, W., Drake, M.E., Henle, G. et al. Evidence for the propagation of the virus of serum hepatitis in the chick embryo. Archiv f Virusforschung 4, 612–620 (1952). https://doi.org/10.1007/BF01242027

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  • DOI: https://doi.org/10.1007/BF01242027

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