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Comparative pharmacokinetics of the anticoagulant effect of coumarin drugs in man and rat

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Abstract

The pharmacokinetic characterization of coumarin drugs may be used as an example of how one may analyze the time course of an indirect effect, having no apparent relationship to the drug concentrations in the plasma, such as is seen for the lowering of prothrombin complex activity. Resolution of the data into measures of the “direct” effect (i.e., inhibition of synthesis of clotting factor activity) permits excellent correlation between effect and drug concentration. The parallel development of a suitable animal model (the rat) has provided the opportunity to study the pharmacokinetics of the anticoagulant effect of the coumarin drugs and of their interaction with other drugs not only in the plasma but also at the tissue level. Selected results of an examination of the kinetics of drug distribution and elimination as well as the kinetics of drug action in both man and animals are presented here for the coumarin drugs as an example of a comprehensive pharmacokinetic investigation.

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, 14214, New York

    Gerhard Levy

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  1. Gerhard Levy
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Levy, G. Comparative pharmacokinetics of the anticoagulant effect of coumarin drugs in man and rat. Journal of Pharmacokinetics and Biopharmaceutics 1, 541–551 (1973). https://doi.org/10.1007/BF01059790

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  • DOI: https://doi.org/10.1007/BF01059790

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