Abstract
The pathogenesis of many infectious diseases is critically determined by prokaryotic lectins which enable differential recognition and activation of targeted eukaryotic cells. Some bacterial adhesins mimic and co-opt eukaryotic cell-cell adhesion motifs. This is illustrated by the toxin ofBordetella pertussis. Pertussis toxin mediates intoxication of eukaryotic cells by elevation of cAMP and it serves as an adhesin binding the bacteria to ciliated cells and respiratory macrophages. These activities are mediated by the lectin-like properties of the binding oligomer of the toxin. A comparison of pertussis toxin and the selectins involved in leukocyte trafficking indicates that these prokaryotic and eukaryotic C-type lectins share some element of primary sequence similarity, three dimensional structure, and biological activities. Such mimicry suggests a link between eukaryotic cell-cell adhesion motifs and microbial pathogenesis.
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Sandros, J., Rozdzinski, E., Zheng, J. et al. Lectin domains in the toxin ofBordetella pertussis: selectin mimicry linked to microbial pathogenesis. Glycoconjugate J 11, 501–506 (1994). https://doi.org/10.1007/BF00731300
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DOI: https://doi.org/10.1007/BF00731300