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Biotransformation of diphenyl ether by the yeastTrichosporon beigelii SBUG 752

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Abstract

Trichosporon beigelii SBUG 752 was able to transform diphenyl ether. By TLC, HPLC, GC, GC-MS, NMR- and UV-spectroscopy, several oxidation products were identified. The primary attack was initiated by a monooxygenation step, resulting in the formation of 4-hydroxydiphenyl ether, 2-hydroxydiphenyl ether and 3-hydroxydiphenyl ether (48:47:5). Further oxidation led to 3,4-dihydroxydiphenyl ether. As a characteristic product resulting from the cleavage of an aromatic ring, the lactone of 2-hydroxy-4-phenoxymuconic acid was identified. The possible mechanism of ring cleavage to yield this metabolite is discussed.

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Authors and Affiliations

  1. Institut f. Mikrobiologie, Ernst-Moritz-Arndt-Universität, Jahnstr. 15a, 0-2200, Greifswald, Germany

    Frieder Schauer & Kirsten Henning

  2. Institut f. Physikalische Chemie, Soldtmannstr. 23, 0-2200, Greifswald, Germany

    Helmut Pscheidl

  3. Institut f. Allgemeine Botanik, Abt. Mikrobiologie, Ohnhorststr. 18, W-2000, Hamburg, Germany

    Rolf M. Wittich & Peter Fortnagel

  4. Institut f. Organische Chemie, Martin-Luther-King-Platz 6, Universität Hamburg, W-2000, Hamburg, Germany

    Heinz Wilkes, Volker Sinnwell & Wittko Francke

Authors
  1. Frieder Schauer
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  2. Kirsten Henning
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  3. Helmut Pscheidl
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  4. Rolf M. Wittich
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  5. Peter Fortnagel
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  6. Heinz Wilkes
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  7. Volker Sinnwell
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  8. Wittko Francke
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Schauer, F., Henning, K., Pscheidl, H. et al. Biotransformation of diphenyl ether by the yeastTrichosporon beigelii SBUG 752. Biodegradation 6, 173–180 (1995). https://doi.org/10.1007/BF00695348

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  • DOI: https://doi.org/10.1007/BF00695348

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