Summary
The RNA content of single nerve cell bodies from the anterior horn of rat spinal cord shows no increase during the 12 weeks of feeding of IDPN (β,β-iminodipropionitrile), but a slight decrease is noted during the last four weeks.
The RNA concentration in the axonal balloons is only 0.23% as compared to 5.3% in the nerve cell body.
The A/U ratio of RNA in the axonal balloons is 0.61 as compared to 0.90 in cell bodies of normal nerve cells. The A/U ratio of RNA in cell bodies of rats fed IDPN is also reduced to 0.68 (6–8 weeks) while the A/U for rats fed IDPN for 1–12 weeks is 0.77.
Zusammenfassung
Der RNS-Gehalt einzelner Nervenzellkörper aus dem Vorderhorn des Rückenmarks der Ratte zeigt keine Zunahme während der 12 wöchigen IDPN (β,β-Iminodipropionitril)-Fütterung, doch wurde während der letzten 4 Wochen eine geringe Verminderung beobachtet.
Die RNS-Konzentration in den Axon-Ballons beträgt 0,23%, verglichen mit 5,3% in den Nervenzellkörpern.
Der Adenin/Uracil (A/U)-Quotient der RNS in den Axonballonen beträgt 0,61 gegenüber 0,90 in den Perikaryen der normalen Nervenzellen. Der A/U-Quotient von RNS in den Zellkörpern von Ratten, die mit IDPN gefüttert wurden, ist auf 0,68 reduziert (6–8 Wochen), während er für Ratten, die 1–12 Wochen lang mit IDPN gefüttert wurden, 0,77 beträgt.
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Hartmann, H.A., Lin, J. & Shively, M.C. RNA of nerve cell bodies and axons after β,β-iminodipropionitrile. Acta Neuropathol 11, 275–281 (1968). https://doi.org/10.1007/BF00686724
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DOI: https://doi.org/10.1007/BF00686724