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Diagnostic imaging using rare-earth chelates

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Abstract

A new class of polyazamacrocyclic chelates of terbium is studied that have rich spectroscopic properties, tissue selectivity [1], millisecond fluorescence lifetimes, sharply spiked emission spectra (<15 nm FWHM), large Stokes shifts (>280 nm), good water solubility [1] and high fluorescence quantum yields (∼0.6 for PCTMB) [1]. We report our in vitro and ex vivo spectroscopic evaluation of these chelates. Additionally, results from cellular binding specificity studies using Sprague-Dawley rats with UMR 108 osteosarcomas are presented. Finally, endoscopic imaging of dosed tissue demonstrates the potential to use the Tb(III) chelates as contrast enhancement markers.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Texas Tech University, 79409-1061, Lubbock, TX, USA

    D. S. Hubbard, M. P. Houlne & D. J. Bornhop

  2. Designed Chemicals R&D, Dow Chemical Company, Freeport

    G. Kiefer

  3. Department of Orthopedics, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

    H. F. Janssen & C. Hacker

Authors
  1. D. S. Hubbard
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  2. M. P. Houlne
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  3. G. Kiefer
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  4. H. F. Janssen
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  5. C. Hacker
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  6. D. J. Bornhop
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Corresponding author

Correspondence to D. J. Bornhop.

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Hubbard, D.S., Houlne, M.P., Kiefer, G. et al. Diagnostic imaging using rare-earth chelates. Laser Med Sci 13, 14–21 (1998). https://doi.org/10.1007/BF00592956

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  • DOI: https://doi.org/10.1007/BF00592956

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