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An Ia-positive mouse T-cell clone is functional in presenting antigen to other T cells

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Abstract

In this report we present data demonstrating the endogenous expression of I-region associated (la) antigens on a cloned line of mouse T cells, CTLL, as well as transcription of the invariant chain gene in these cells. We demonstrate further that this Ia-bearing T-cell clone, CTLL, can utilize the expressed la molecules to present antigen to la-restricted antigen-specific T cells.

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Abbreviations

Ia:

I-region associated

Ir :

genes, immune response genes

Ii:

invariant chain

MHC:

major histocompatibility complex

APC:

antigen-presenting cells

mAB:

monoclonal antibody

IL-2:

interleukin 2

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Authors and Affiliations

  1. Department of Genetics, Harvard Medical School, USA

    Avraham Ben-Nun, William Strauss, Cornelis Murre, Allan Duby & J. G. Seidman

  2. Laboratory of Tumor Immunology, Dana Farber Cancer Institute, USA

    Sara A. Leeman

  3. Department of Cancer Biology, Harvard School of Public Health, 02115, Boston, Massachusetts

    Lauren E. Cohn & Laurie H. Glimcher

Authors
  1. Avraham Ben-Nun
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  2. William Strauss
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  3. Sara A. Leeman
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  4. Lauren E. Cohn
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  5. Cornelis Murre
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  6. Allan Duby
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  7. J. G. Seidman
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  8. Laurie H. Glimcher
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Ben-Nun, A., Strauss, W., Leeman, S.A. et al. An Ia-positive mouse T-cell clone is functional in presenting antigen to other T cells. Immunogenetics 22, 123–130 (1985). https://doi.org/10.1007/BF00563509

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  • DOI: https://doi.org/10.1007/BF00563509

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