Abstract
A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designatedMgd1, is expressed in liver and kidney. Inbred rat strains have fixed either alleleMgd1 a or alleleMgd1 b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence thatMgd1 is linked toPep3 andFh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases:Mgd2, present in liver and kidney, andMgd3, present only in heart.
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Supported by the Deutsche Forschungsgemeinschaft (Grant Be 352/18-1).
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Bender, K., Seibert, R.T., Wienker, T.F. et al. Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus). Biochem Genet 32, 147–154 (1994). https://doi.org/10.1007/BF00554618
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DOI: https://doi.org/10.1007/BF00554618