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Screening of inbred rat strains for electrophoretic protein polymorphisms

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Abstract

Nineteen inbred strains of the laboratory rat (Rattus norvegicus) were investigated for genetic differences by starch and agarose gel electrophoretic techniques. For six out of 21 loci, interstrain differences were observed: Tf, 6PGD, Es-1, Es-4, Es-5, and Svp. The variants are briefly described and the allelic distributions are tabulated. The 6GPD locus was found to be linked neither to the major histocompatibility gene region nor to the coat color genes c, a, h.

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References

  • Augustinsson, K. B., and Henricson, B. (1966) A genetically controlled esterase in rat plasma. Biochim. Biophys. Acta 124323.

    Google Scholar 

  • Bender, K., Mayerová, A., Frank, R., Hiller, C., and Wienker, T. (1977). Haplotype analysis of the linkage group HLA-A: HLA-B: Bf and its bearing on the interpretation of the linkage disequilibrium. Hum. Genet. 36191.

    Google Scholar 

  • Brdička, R. (1974). Alleles of the second plasma esterase locus in the laboratory rat and their distribution among some inbred strains. Folia Biol. (Praha) 20350.

    Google Scholar 

  • Brdička, R., and Sulk, K. (1965). Different haemoglobin patterns in inbred lines of rats. Folia Biol. (Praha) 11328.

    Google Scholar 

  • Carter, N. D., and Parr, C. W. (1969). Phosphogluconate dehydrogenase polymorphism in British wild rats. Nature 224214.

    Google Scholar 

  • Doležalová, V., and Brada, Z. (1968). Serum protein heterogeneity in some inbred rat strains studied by electrophoretic methods. Comp. Biochem. Physiol. 26301.

    Google Scholar 

  • Eriksson, K., Halkka, O., Lokki, J., and Saura, A. (1976). Enzyme polymorphism in feral, outbred and inbred rats (Rattus norvegicus). Heredity 37341.

    Google Scholar 

  • French, E. A., Roberts, K. B., and Searle, A. G. (1971). Linkage between a hemoglobin locus and albinism in the Norway rat. Biochem. Genet. 5397.

    Google Scholar 

  • Gasser, D. L. (1972). Seminal vesicle protein in rats: A gene in the fourth linkage group determining electrophoretic variants. Biochem. Genet. 661.

    Google Scholar 

  • Gasser, D. L., Silvers, W. K., Reynolds, H. U., Jr., Black, G., and Palm, J. (1973). Serum esterase genetics in rats: Two new alleles at Es-2, a new esterase regulated by hormonal factors, and linkage of these loci to the Ag-C blood group locus. Biochem. Genet. 10207.

    Google Scholar 

  • Günther, E., and Štark, O. (1977). The major histocompatibility system of the rat (Ag-B or H-I system). In Götze, D. (ed.), The Major Histocompatibility System in Man and Animals Springer-Verlag, Heidelberg.

    Google Scholar 

  • Harris, H., and Hopkinson, D. A. (1976). Handbook of Enzyme Electrophoresis in Human Genetics North-Holland, Amsterdam.

    Google Scholar 

  • Howard, J. C. (1971). A histocompatible chromosome marker system in the laboratory rat Rattus norvegicus. Transplantation 1295.

    Google Scholar 

  • Jimenez-Marin, D. (1974). Enzyme inheritance in the laboratory rat: Genetics of a heart aromatic esterase and plasma alkaline phosphatase in substrains of Rattus norvegicus. J. Hered. 65235.

    Google Scholar 

  • Jimenez-Marin, D., and Dessauer, H. C. (1973). Protein phenotype variation in laboratory populations of Rattus norvegicus. Comp. Biochem. Physiol. 46B487.

    Google Scholar 

  • Koga, A., Harada, S., and Omoto, K. (1972). Polymorphisms of erythrocyte 6-phosphogluconate dehydrogenase and phosphoglucomutase in Rattus norvegicus in Japan. Japan. J. Genet. 46335.

    Google Scholar 

  • Moutier, R., Toyama, K., and Charrier, M. F. (1973a). Biochemical polymorphism in the rat, Rattus norvegicus: Genetic study of four markers. Biochem. Genet. 8321.

    Google Scholar 

  • Moutier, R., Toyama, K., and Charrier, M. F. (1973b). Evidence for linkage between four esterase loci in the rat (Rattus norvegicus). Biochem. Genet. 9109.

    Google Scholar 

  • Moutier, R., Toyama, K., and Charrier, M. F. (1973c). Himalayan allele at the albino locus in the Norway rat. J. Hered. 64303.

    Google Scholar 

  • Nichols, E. A., and Ruddle, F. H. (1973). A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels. J. Histochem. Cytochem. 211066.

    Google Scholar 

  • Palm, J., and Ferguson, F. G. (1976). Fuzzy, a hypotrichotic mutant in linkage group I of the Norway rat. J. Hered. 67284.

    Google Scholar 

  • Robinson, R. (1965). Genetics of the Norway Rat Pergamon Press, Oxford.

    Google Scholar 

  • Serov, O. L. (1973). Genetic control of two esterases of rat plasma (Rattus norvegicus). Biochem. Genet. 9117.

    Google Scholar 

  • Shaw, C. R., and Prasad, R. (1970). Starch gel electrophoresis of enzymes—A compilation of recipes. Biochem. Genet. 4297.

    Google Scholar 

  • Teisberg, P. (1970). High voltage agarose gel electrophoresis in the study of C3 polymorphism. Vox Sang. (Basel) 1947.

    Google Scholar 

  • Womack, J. E. (1971). Evidence for a second serum esterase locus in Rattus norvegicus. Genetics 68975.

    Google Scholar 

  • Womack, J. E. (1972a). Genetic control of an esterase of digestive tract tissues in Rattus norvegicus. Experientia 281372.

    Google Scholar 

  • Womack, J. E. (1972b). Genetic control of the major electrophoretic component of rat plasma esterase. J. Hered. 6341.

    Google Scholar 

  • Womack, J. E. (1973). Biochemical genetics of rat esterases: Polymorphism, tissue expression, and linkage of four loci. Biochem. Genet. 913.

    Google Scholar 

  • Womack, J. E., and Sharp, M. (1976). Comparative autosomal linkage in mammals: Genetics of esterases in Mus musculus and Rattus norvegicus. Genetics 82665.

    Google Scholar 

  • Yamori, Y., and Okamoto, K. (1970). Zymogram analyses of various organs from spontaneously hypertensive rats: A genetico-biochemical study. Lab. Invest. 22206.

    Google Scholar 

  • Yasnova, M. V., and Gileva, E. A. (1976). Chromosome polymorphism in two synanthropous populations of Norway rat (Rattus norvegicus Berk.) Genetica (Moskow) 12165.

    Google Scholar 

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This investigation was supported by the Deutsche Forschungsgemeinschaft (Be 352/10 and Gu 105).

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Bender, K., Günther, E. Screening of inbred rat strains for electrophoretic protein polymorphisms. Biochem Genet 16, 387–398 (1978). https://doi.org/10.1007/BF00484206

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  • DOI: https://doi.org/10.1007/BF00484206

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