Skip to main content
SpringerLink
Log in

Lack of effect of a highly purified yeast RNA preparation on maze learning

  • Short Communications
  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Summary

Mice injected with 280 mg/kg of highly purified yeast RNA learned to avoid shock by choosing a white rather than a black door in a Y-maze at the same rate as saline-injected controls. The generality and interpretation of reports on enhancement of acquisition following RNA injection is questioned.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Barondes, S. H., and M. E. Jarvik: The influence of Actino-mycin-D on brain RNA-synthesis and on memory. J. Neurochem. 11, 187–195 (1964).

    Google Scholar 

  • Beavav, G. H., E. R. Holiday, and E. A. Johnson: Optical properties of nucleic acids and their components. In E. Chargaff and J. N. Davidson (Eds.): The Nucleic Acids, Vol. I, pp. 493–553. New Tork: Academic Press 1955.

    Google Scholar 

  • Cameron, D. E., L. Solyom, S. Sved, and B. Wainrib: Effects of intravenous administration of ribonucleic acid upon failure of memory for recent events in presenile and aged individuals. In J. Wortis (Ed.): Recent Advances in Biological Psychiatry, Vol. V, pp. 365–374 (1963a).

  • —, S. Sved, L. Solyom, B. Wainrib, and H. Barik: Effects of ribonucleic acid on memory defect in the aged. Amer. J. Psychiat. 120, 320–325 (1963b).

    Google Scholar 

  • Cook, L., A. B. Davidson, D. V. Davis, L. Green, and E. V. Fellows: Ribonucleic acid: effect on conditioned behavior in rats. Science 141, 268–269 (1963).

    Google Scholar 

  • Lowry, O. H., N. V. Rosenbrough, A. L. Farr, and R. V. Randall: Protein measurement with the Folin phenol reagent. J. biol. Chem. 193, 265–275 (1951).

    Google Scholar 

  • Schneider, W. C.: Determination of nucleic acids in tissues by pentose analysis. In S. P. Colowick and N. O. Kaplan (Eds.): Methods in Enzymology, Vol. III, pp. 680–684. New York: Academic Press 1957.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Psychiatry and Research Laboratory McLean Hospital, Belmont, Mass.

    Harry D. Cohen & Samuel H. Barondes

  2. Dept. of Psychiatry, Harvard University, USA

    Harry D. Cohen & Samuel H. Barondes

  3. Tufts University, Medford, Mass., USA

    Harry D. Cohen

Authors
  1. Harry D. Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Samuel H. Barondes
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by General Research Support Grant FR-05484 from the U.S.P.H.S.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cohen, H.D., Barondes, S.H. Lack of effect of a highly purified yeast RNA preparation on maze learning. Psychopharmacologia 8, 375–378 (1965). https://doi.org/10.1007/BF00453513

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00453513

Keywords

Search

Navigation