Abstract
Intraventricular infusions of heroin (an opiate) or levorphanol (an opioid) in rats produced rigidity but not explosive motor behavior (EMB). When preceded by an IP injection of naloxone, infusions of heroin but not levorphanol produced EMB. The results suggest that naloxone-antagonized effects of opiates mask EMB and that certain opioids do not induce EMB.
References
Blair, R., Cytryniak, H., Shigal, P., Amit, Z.: Naloxone's antagonism of rigidity but not explosive motor behavior: Possible evidence for two types of mechanisms underlying the actions of opiates and opioids. Behav. Biol. 24, 24–31 (1978a)
Blair, R., Liran, J.: Explosive motor behavior and rigidity produced by morphine and etonitazene: Interaction with lesions of the periaqueductal gray. Paper presented at the 48 th Annual Meeting of the Eastern Psychological Association, Boston, Mass. (1977)
Blair, R., Liran, J., Cytryniak, H., Shizgal, P., Amit, Z.: Explosive motor behavior, rigidity and periaqueductal gray lesions. Neuropharmacology 17, 205–209 (1978b)
Jacquet, Y. F.: Opiate effects after adrenocorticotropin or β-endorphin injection in the periaqueductal gray matter of rats. Science 201, 1032–1034 (1978)
Jacquet, Y. F., Klee, W. A., Rice, K. C., Iijima, I., Minamikawa, J.: Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: Evidence for a new class of receptors? Science 198, 842–845 (1977)
Jacquet, Y. F., Lajtha, A.: Paradoxical effects after microinjections of morphine in the periaquaductal gray matter in the rat. Science 185, 1055–1057 (1974)
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Blair, R., Cytryniak, H., Shizgal, P. et al. Heroin, but not levorphanol, produces explosive motor behavior in naloxone-treated rats. Psychopharmacology 69, 313–314 (1980). https://doi.org/10.1007/BF00433102
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DOI: https://doi.org/10.1007/BF00433102