Abstract
Levels of prolactin (PRL) in plasma were determined in schizophrenic women and men after i.m. injections of 50–150 mg perphenazine enanthate (PE). In both sexes PRL levels increased dose-dependently. In men the effect was significant for 2 and in women for 9 days. Biperiden treatment did not influence the effect of PE on the PRL levels. The data support the view that clinically used doses of PE induce a small but significant blockade of central dopamine receptors.
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Lindholm, H., Gullberg, B., Öhman, A. et al. Effects of perphenazine enanthate injections on prolactin levels in plasma from schizophrenic women and men. Psychopharmacology 57, 1–4 (1978). https://doi.org/10.1007/BF00426949
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DOI: https://doi.org/10.1007/BF00426949