Skip to main content
SpringerLink
Log in

Impaired performance by post-trial injections of cycloheximide in a passive avoidance task

  • Original Investigations
  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Summary

Cycloheximide, injected subcutaneously after training in a passive avoidance task resulted in impaired performances on the retest given 7 days later. A gradient was observed for this effect, injections given immediately after training producing most impairment and injections given 2 h after training producing none.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Agranoff, B. W., R. E. Davis, L. Casola, and R. Lim: Actinomycin D blocks formation of memory of shock-avoidance in goldfish. Science 158, 1600–1601 (1967).

    PubMed  Google Scholar 

  • Barondes, S. H., and H. D. Cohen: Delayed and sustained effect of acetoxy-cycloheximide on memory in mice. Proc. nat. Acad. Sci. (Wash.) 58, 157–164 (1967).

    Google Scholar 

  • — —: Memory impairment after subcutaneous injection of acetoxycycloheximide. Science 160, 556–557 (1968).

    PubMed  Google Scholar 

  • Cohen, H. D., and S. H. Barondes: Cycloheximide impairs memory of an appetitive task. Comm. Behav. Biol. 1, 337–339 (1968).

    Google Scholar 

  • Jarvik, M. E., and R. Kopp: An improved one-trial passive avoidance learning situation. Psychol. Rep. 21, 221–224 (1967).

    PubMed  Google Scholar 

  • Kopp, R., Z. Bohdanecky, and M. E. Jarvik: Long temporal gradient of retrograde amnesia for a well discriminated stimulus. Science 153, 1547–1549 (1966).

    PubMed  Google Scholar 

  • Wilcoxcon, F., S. K. Katti, and R. A. Wilcox: Critical values and probability levels for the Wilcoxon Rank Sum Test and the Wilcoxon Rank Test. Lederle Laboratories Division, American Cyanamid Co., August 1964.

  • Young, C. W., P. F. Robinson, and B. Sacktor: Inhibition of the synthesis of protein in intact animals by acetoxycycloheximide and a metabolic derangement concomitant with this blockade. Biochem. Pharmacol. 12, 855–865 (1963).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pharmacology and Psychiatry, Albert Einstein College of Medicine, 10461, Bronx, N. Y.

    Anne Geller, F. Robustelli, S. H. Barondes, H. D. Cohen & M. E. Jarvik

Authors
  1. Anne Geller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Robustelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. H. Barondes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. D. Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. E. Jarvik
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This research was supported by USPHS Research Grant MH 05319, 5T1 MH 6418, MH 01225, and MH 12773 and Career Development Award K3 MH 18232.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Geller, A., Robustelli, F., Barondes, S.H. et al. Impaired performance by post-trial injections of cycloheximide in a passive avoidance task. Psychopharmacologia 14, 371–376 (1969). https://doi.org/10.1007/BF00403577

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00403577

Key-Words

Search

Navigation