Abstract
We report a case of a 69-year-old woman with an 11-year history of progressive dementia, who was found at autopsy to have classic Pick's disease pathology, as well as extensive paired helical filament-immunoreactive neurities, with few Alzheimer's disease (AD)-like neurofibrillary tangles and no senile plaques. Both Pick bodies and neuritic degeneration were extensive in the neocortex and hippocampal complex. In addition, synaptophysin immunostaining of the hippocampal complex showed a bilaminar pattern of immunoreactivity in the outer molecular layer as previously described in AD.
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Braak H, Braak E (1988) Neuropil threads occur in dendrites of tangle-bearing nerve cells. Neuropathol Applied Neurobiol 14: 39–44
Braak H, Braak E, Grundke-Iqbal I, Iqbal K (1986) Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 65: 351–355
Cabalka LM, Hyman BT, Goodlett CR, Ritchie TC, Van Hoesen GW (1992) Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions. Neurobiol Aging 13: 283–291
Davis DG, Wang HZ, Markesbery WR (1992) Image analysis of neuropil threads in Alzheimer's, Pick's, diffuse Lewy body disease and in progressive supranuclear palsy. J Neuropathol Exp Neurol 51: 594
Greenberg SG, Davies P, Schein JD, Binder LI (1992) Hydrofluoric acid-treated τPHF proteins display the same biochemical properties as normal τ*. J Biol Chem 267: 564–569
Hof PR, Bouras C, Perl DP, Morrison JH (1994) Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. Acta Neuropathol 87: 115–124
Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 225: 1168–1170
Hyman BT, Tanzi RE, Marzloff K, Barbour R, Schenk D (1992) Kunitz protease inhibitor-containing amyloid β protein precursor immunoreactivity in Alzheimer's disease. J Neuropathol Exp Neurol 51: 76–83
Jellinger KA (1994) Quantitative neuropathologic analysis of Pick's disease cases. Acta Neuropathol 87: 223–224
Joachim CL, Mori H, Selkoe DJ (1989) Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease. Nature 341: 226–230
Kowall NW, Kosik KS (1987) Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol 22: 639–643
Levey AI, Bolam JP, Rye DB, Hallanger AE, Demuth RM, Mesulam MM, Wainer BH (1986) A light and electron microscopic procedure for sequential double antigen localization using diaminobenzidine and benzidine dihydrochloride. J Histochem Cytochem 34: 1449–1457
Masliah E, Terry RD, Alford M, DeTeresa R, Hansen LA (1991) Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. Am J Pathol 138: 235–246
Mori H, Kondo J, Ihara Y (1987) Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 235: 1641–1644
Mufson EJ, Mash DC, Hersh LB (1988) Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease. Ann Neurol 24: 623–629
Mufson EJ, Bothwell M, Hersh LB, Kordower JH (1989) Nerve growth factor receptor immunoreactive profiles in the normal aged human basal forebrain: colocalization with cholinergic neurons. J Comp Neurol 285: 196–217
Murayama S, Mori H, Ihara Y, Tomonaga M (1990) Immunocytochemical and ultrastructural studies of Pick's disease. Ann Neurol 27: 394–405
Perry G, Stewart D, Friedman R, Manetto V, Autilio-Gambetti L, Gambetti P (1987) Filaments of Pick's bodies contain altered cytoskeletal elements. Am J Pathol 127: 559–568
Schmidt ML, Lee VM, Trojanowski JQ (1991) Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads. Lab Invest 64: 352–357
Weiler R, Lassmann H, Fischer P, Jellinger K, Winkler H (1990) A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease. FEBS Lett 263: 337–339
Wolozin B, Davies P (1987) Alzheimer-related neuronal protein A68: specificity and distribution. Ann Neurol 22: 521–526
Yamaguchi H, Nakazato Y, Shoji M, Ihara Y, Hirai S (1990) Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques. Acta Neuropathol 80: 368–374
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Supported by grants AG09466, AG10161, AG10688, and AG11482
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Cochran, E.J., Fox, J.H. & Mutson, E.J. Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity. Acta Neuropathol 88, 479–484 (1994). https://doi.org/10.1007/BF00389503
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DOI: https://doi.org/10.1007/BF00389503