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Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity

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Abstract

We report a case of a 69-year-old woman with an 11-year history of progressive dementia, who was found at autopsy to have classic Pick's disease pathology, as well as extensive paired helical filament-immunoreactive neurities, with few Alzheimer's disease (AD)-like neurofibrillary tangles and no senile plaques. Both Pick bodies and neuritic degeneration were extensive in the neocortex and hippocampal complex. In addition, synaptophysin immunostaining of the hippocampal complex showed a bilaminar pattern of immunoreactivity in the outer molecular layer as previously described in AD.

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Authors and Affiliations

  1. Rush Alzheimer's Disease Center, Rush Presbyterian-St. Luke's Medical Center, 60612, Chicago, IL, USA

    Elizabeth J. Cochran, Jacob H. Fox & Elliott J. Mutson

  2. Department of Neurological Sciences, Rush Presbyterian-St. Luke's Medical Center, 2242 W. Harrison St., 60612, Chicago, IL, USA

    Elizabeth J. Cochran, Jacob H. Fox & Elliott J. Mutson

  3. Department of Pathology, Rush Presbyterian-St. Luke's Medical Center, 60612, Chicago, IL, USA

    Elizabeth J. Cochran

Authors
  1. Elizabeth J. Cochran
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  2. Jacob H. Fox
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  3. Elliott J. Mutson
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Supported by grants AG09466, AG10161, AG10688, and AG11482

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Cochran, E.J., Fox, J.H. & Mutson, E.J. Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity. Acta Neuropathol 88, 479–484 (1994). https://doi.org/10.1007/BF00389503

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  • DOI: https://doi.org/10.1007/BF00389503

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