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Developmental dyslexia, neurolinguistic theory and deviations in brain morphology

  • Part Two: Neurology/Neuropsychology
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Abstract

Although some form of central nervous system involvement is presumed, evidence establishing a relationship between dyslexia and neurological dysfunction has been correlational. Recently, neuroimaging and postmortem studies have begun to provide direct evidence implicating neuropathological structures in dyslexia. This article reviews computed tomography (CT) and magnetic resonance imaging (MRI) studies examining deviations in brain morphology which appear to be associated with neurolinguistic functioning. Methodological and technical issues are discussed. Based on their own and others research, the authors conclude that dyslexics show variations in specific brain regions, namely, reversed or symmetrical plana temporale (L≤R), smaller insular length bilaterally, and symmetrical frontal regions. Moreover, recent studies by the senior author and colleagues suggest that specific reading tasks are associated with specific variations in brain morphology. Symmetrical frontal widths was related to poorer passage comprehension, and reversed frontal area symmetry was related to poor word attack skills. Though many conceptual and technical issues remain unresolved, neuroimaging procedures appear to provide direct evidence supporting the importance of deviations in normal patterns of brain morphology in dyslexia.

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References

  • Campbell S., and Whitaker H. (1986). Cortical maturation and developmental neurolinguistics. In J. E. Obrzut and G. W. Hynd (eds.), Child Neuropsychology: Theory and Research Vol. 1, pp. 55–72. New York: Academic Press.

    Google Scholar 

  • Chui H. C., and Damasio A. R. (1980). Human cerebral asymmetries evaluated by computerized tomography. Journal of Neurology, Neurosurgery, and Psychiatry, 43, 873–878.

    Google Scholar 

  • Corballis M. C., and Beale I. C. (1976). The Psychology of Left and Right. Hillsdale, NJ: Erlbaum.

    Google Scholar 

  • Coren S., Porac C., and Duncan P. (1979). A behaviorally validated self-report inventory to assess four types of lateral preference. Journal of Clinical Neuropsychology, 1, 33–64.

    Google Scholar 

  • Denckla M. B., LeMay M., and Chapman C. A. (1985). Few CT scan abnormalities found even in neurologically impaired learning disabled children. Journal of Learning Disabilities, 18, 132–135.

    Google Scholar 

  • Eidelberg D., and Galabruda A. M. (1982). Symmetry and asymmetry in the human posterior thalamus: I Cytoarchitectonic analysis in normal persons. Archives of Neurology, 39, 325–332.

    Google Scholar 

  • Evans W. A. (1942). An encephalographic ratio for estimating ventricular enlargement and cerebral atrophy. Archives of Neurology, 47, 931–937.

    Google Scholar 

  • Falzi G., Perrone P., and Vignolo L. A. (1982). Right-left asymmetry in anterior speech region. Archives of Neurology, 39, 239–240.

    Google Scholar 

  • Filipek P. A., Kennedy D. N., Caviness V. S., Rossnick S. L., Spraggins T. A., Starewicz P. M. (1989). Magnetic resonance imaging-based brain morphology: Development and application to normal subjects. Annals of Neurology, 25, 61–67.

    Google Scholar 

  • Fleschig P. (1908). Zentrablatt Neurologie-Psychiatrie, 27, 50.

    Google Scholar 

  • Galaburda A. M., and Kemper T. L. (1979). Cytoarchitectonic abnormalities in developmental dyslexia: a case study. Annals of Neurology, 6, 94–100.

    Google Scholar 

  • Galaburda A., and Sanides F. (1980). Cytoarchitectonic organization of the human auditory cortex. Journal of Comparative Neurology, 190, 597–610.

    Google Scholar 

  • Galaburda A. M., Sherman G. F., Rosen G. D., Aboitiz F., Geschwind N. (1985). Developmental dyslexia: Four consecutive patients with cortical abnormalities. Annuals of Neurology, 18, 222–233.

    Google Scholar 

  • Galaburda A. M., Corsiglia J., Rosen G. D., and Serman G. F. (1987). Planum temporale asymmetry, reappraisal since Geschwind and Levitsky. Neuropsychologia, 25, 853–868.

    Google Scholar 

  • Geschwind N. (1974). The development of the brain and the evolution of language. In N. Geschwind (eds.), Selected Papers on Language and the Brain. Dordrecht, The Netherlands: D. Reidel.

    Google Scholar 

  • Geschwind N. (1984). Cerebral dominance in biological perspective. Neuropsychologia, 22, 675–683.

    Google Scholar 

  • Geschwind N., and Behan P. O. (1982). Left handedness: Association with immune disease, migraine, and developmental learning disorders. proceedings of the National Academy of Sciences, 79, 5097–5100.

    Google Scholar 

  • Geschwind N., and Galaburda A. M. (1985a). Cerebral lateralization: Biological mechanisms, associations, and pathology: I. A hypothesis and a program for research. Archives of Neurology, 42, 428–459.

    Google Scholar 

  • Geschwind N., and Galaburda A. M. (1985b). Cerebral lateralization: Biological mechanisms, associations, and pathology: II. A hypothesis and a program for research. Archives of Neurology, 42, 521–552.

    Google Scholar 

  • Geschwind N., and Galaburda A. M. (1985c). Cerebral lateralization: Biological mechanisms, associations, and pathology: III. A hypothesis and a program for research. Archives of Neurology, 42, 634–654.

    Google Scholar 

  • Geschwind N., and Levitsky W. (1968). Human brain: Left-right asymmetries in temporal speech region. Science, 161, 186–187.

    Google Scholar 

  • Golden G. S. (1982). Neurobiological correlates of learning disabilities. Annals of Neurology, 12, 409–418.

    Google Scholar 

  • Gross-Glenn K., Duara R., Yoshii F., Baker W. W., Chang J. Y., Apicella A., Boothe T., and Lubs H. A. (1986). PET-scan studies during reading in dyslexic and nondyslexic adults [abstract], Neuroscience, 24, 371.

    Google Scholar 

  • Hardyck C., Petrinovitch L. F., and Goldman R. (1976). Left handedness and cognitive deficit. Cortex, 12, 266–278.

    Google Scholar 

  • Harris T. L., and Hodges R. E. (eds.). (1981). A Dictionary of Reading and Related Terms. Newark, NJ: International Reading Association.

    Google Scholar 

  • Haslam R. H., Dalby J. T., Johns R. D., and Rademaker A. W. (1981). Cerebral asymmetry in developmental dyslexia. Archives of Neurology, 38, 679–682.

    Google Scholar 

  • Hier D. B., LeMay M., Rosenberger P. B., and Perlo V. P. (1978). Developmental dyslexia: Evidence for a subgroup with a reversal of cerebral asymmetry. Archives of Neurology, 35, 90–92.

    Google Scholar 

  • Hynd G. W., and Semrud-Clikeman M. (1989a). Dyslexia and neurodevelopmental pathology: Relationships to cognition, intelligence and reading skill acquisition. Journal of Learning Disabilities, 22, 204–216.

    Google Scholar 

  • Hynd G. W., and Semrud-Clikeman M. (1989b). Dyslexia and brain morphology. Psychological Bulletin, 106, 447–482.

    Google Scholar 

  • Hynd G. W., Semrud-Clikeman M., Lorys A. R., Novey E. S., and Eliopulos D. (1990). Brain morphology in developmental dyslexia and attention deficit disorder/hyperactivity. Archives of Neurology, 47, 919–926.

    Google Scholar 

  • Kinsbourne M., and Hiscock M. (1981). Cerebral lateralization and cognitive development: Conceptual and methodological issues. In G. W. Hynd and J. E. Obrzut (eds.), Neuropsychological Assessment and the School-Age Child: Issues and Procedures (pp. 125–166). New York: Grune and Stratton.

    Google Scholar 

  • Kopp N., Michel F., Carrier H., Biron A., and Duvillard P. (1977). Etude de certaines asymetries hemispheriques du cerveau humain. Journal of the Neurological Sciences, 34, 349–363.

    Google Scholar 

  • Kuperman S., Gaffney G. R., Hamden-Allen G., Preston D. F., and Venkatesh L. (1990). Neuroimaging in child and adolescent psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 159–172.

    Google Scholar 

  • Larsen J. P., Høien T., Lundberg I., and Odegaard H. (1990). MRI evaluation of the size and symmetry of the planum temporale in adolescents with developmental dyslexia. Brain and Language, 39, 289–301.

    Google Scholar 

  • Leisman G., and Ashkenazi M. (1980). Aetiological factors in dyslexia: IV. Cerebral hemispheres are functionally equivalent. Neuroscience, 11, 157–164.

    Google Scholar 

  • LeMay M. (1976). Morphological cerebral asymmetries of modern man, fossil man, and nonhuman primates. Annals of the New York Academy of Science, 280, 349–366.

    Google Scholar 

  • LeMay M. (1981). Are there radiological changes in the brains of individuals with dyslexia? Bulletin of the Orton Society, 31, 135–141.

    Google Scholar 

  • Lingam S., Read S., Holland I. M., Wilson J., Brett E. M., and Hoare R. D. (1982). Value of computerized tomography in children with non-specific mental subnormality. Archives of Disease in Childhood, 57, 381–383.

    Google Scholar 

  • Lou H. C., Henriksen L. and Bruhn P. (1984). Focal cerebral hypoperfusion in children with dysphasia and/or attention deficit disorder. Archives of Neurology, 41, 852–829.

    Google Scholar 

  • Lou H. C., Henriksen L., and Bruhn P. (1989). Striatal dysfunction in attention deficit and hyperkinetic disorder. Archives of Neurology, 46, 48–52.

    Google Scholar 

  • Moeschler J. B., Bennett F. C. and Cromwell L. P. (1981). Use of the CT scan in the medical evaluation of the mentally retarded child. The Journal of Pediatrics, 98, 63–65.

    Google Scholar 

  • Morris R., Blashfield R., and Satz P. (1986). Developmental classfication of readingdisabled children. Journal of Clinical and Experimental Neuropsychology, 8, 371–392.

    Google Scholar 

  • Naeser M. A. and Hayward R. W. (1978). Lesion localization in aphasia with cranial computed tomography and the Boston Diagnostic Aphasia Examination, Neurology, 28, 545–551.

    Google Scholar 

  • Parkins, R., Roberts, R. J., Reinarz, S. J. and Varney, N. R. (1987, January). CT asymmetries in adult developmental dyslexics. Paper presented at the annual convention of the International Neuropsychological Society, Washington, DC.

  • Pieniadz J. M. and Naeser M. A. (1984). Computed tomographic scan cerebral asymmetries and morphological brain asymmetries. Archives of Neurology, 41, 403–409.

    Google Scholar 

  • Pieniadz J. M., Naeser M. A., Koff E., and Levine H. L. (1983). CT scan cerebral hemispheric asymmetry measurements in stroke cases with global aphasia: Atypical asymmetries associated with improved recovery. Cortex, 19, 371–391.

    Google Scholar 

  • Rosenberger P. B. and Hier D. B. (1980). Cerebral asymmetry and verbal intellectual deficits. Annals of Neurology, 8, 300–304.

    Google Scholar 

  • Rubens A. B., Mahuwold M. W., and Hutton J. T. (1976). Asymmetry of the lateral (sylvian) fissures in man. Neurology, 26, 620–624.

    Google Scholar 

  • Rumsey J. M., Dorwart R., Vermess M., Denckla M. B., Kruesi M. J. P., and Rapoport J. L. (1986). Magnetic resonance imaging of brain anatomy in severe developmental dyslexia. Arhives of Neurology, 43, 1045–1046.

    Google Scholar 

  • Semrud-Clikeman, M., Hynd, G. W., Novey, E. S., and Eliopulos, D. (in press). Dyslexia and brain morphology: Relationships between neuroanatomical variation and neurolinguistic tasks. Learning and Individual Differences.

  • Steinmetz H., Ebeling U., Huang Y. and Kahn T. (1990). Sulcus topography of the parietal opercular region: An anatomic and MR study. Brain and Language, 38, 515–533.

    Google Scholar 

  • Synek V., Reuben J. R., and Duboulay G. H. (1976). Comparing Evan's index and computerized axial tomography in assessing relationships of ventricular size to brain size. Neurology, 26, 231–233.

    Google Scholar 

  • Taylor H. G., Fletcher J. M. (1983). Biological foundations of “specific developmental disorders”: Methods, findings, and future directions. Journal of Clinical Child Psychology, 12, 46–65.

    Google Scholar 

  • Teszner D., Tzavaras A., Gruner J., and Hecaen H. (1972). L'asymetri droite-gauche du planum temporale: A propos de l'etude anatomique de 100 cerveaux. Revue Neurologique, 126, 444–449.

    Google Scholar 

  • Von Economo C., and Horn L. (1930). Zeitschrift fur die gesamte Neurologie und Psyuchiatrie, 130, 678.

    Google Scholar 

  • Wada J. A., Clarke R., and Hamm A. (1975). Cerebral hemispheric asymmetry in humans. Archives of Neurology, 32, 239–246.

    Google Scholar 

  • Weinberger D. R., Luchins D. J., Morihisa J., and Wyatt R. J. (1982). Asymmetrical volumes of the right and left frontal and occipital regions of the human brain. Neurology, 11, 97–100.

    Google Scholar 

  • Witelson S. F. (1982). Bumps on the brain: Right-left anatomic asymmetry as a key to functional laterialization. In S. Segalowitz (eds.), Language Functions and Brain Organization (pp. 117–144). New York: Academic Press.

    Google Scholar 

  • Witelson S. F. and Pallie W. (1973). Left hemisphere specialization for language in the newborn. Brain, 96, 641–646.

    Google Scholar 

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Authors and Affiliations

  1. Medical College of Georgia, University of Georgia, Athens, USA

    George W. Hynd

  2. University of Georgia, Athens, USA

    Richard M. Marshall

  3. Massachusetts General Hospital, Boston, USA

    Margaret Semrud-Clikeman

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  1. George W. Hynd
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  2. Richard M. Marshall
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Hynd, G.W., Marshall, R.M. & Semrud-Clikeman, M. Developmental dyslexia, neurolinguistic theory and deviations in brain morphology. Reading and Writing: An Interdisciplinary Journal 3, 345–362 (1991). https://doi.org/10.1007/BF00354967

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