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Chromosomal locations of the gene coding for the CD3 (T3) γ subunit of the human and mouse CD3/T-cell antigen receptor complexes

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Abstract

The gene coding for the M r 26000 γ chain of the human CD3 (T3) antigen/T-cell antigen receptor complex was mapped to chromosome band 11q23 by using a cDNA clone (pJ6T3 γ-2), by in situ hybridization to metaphase chromosomes and by Southern blot analysis of a panel of human-rodent somatic cell hybrids. The mouse homolog, here termed Cdg-3, was mapped to chromosome 9 using the mouse γ cDNA clone pB10.AT3 γ-1 and a panel of mouse-hamster somatic cell hybrids. Similar locations for the CD3 δ genes have been described previously. Thus, the corporate results indicate that the CD3 γ and δ genes have remained together since they duplicated about 200 million years ago.

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Authors and Affiliations

  1. Cell Surface Biochemistry Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, P.O. Box 123, WC2A 3PX, London, UK

    Geoffrey W. Krissansen & Michael J. Crumpton

  2. Human Cytogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, P.O. Box 123, WC2A 3PX, London, UK

    Patricia A. Gorman & Denise Sheer

  3. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20205, Bethesda, Maryland, USA

    Christine A. Kozak

  4. Human Genetic Resources Laboratory, Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Potters Bar, Herts., UK

    Nigel K. Spurr

  5. Laboratory of Human Molecular Genetics, Imperial Cancer Research Fund, Lincoln's Inn Fields, P.O. Box 123, WC2A, London, UK

    Peter N. Goodfellow

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  1. Geoffrey W. Krissansen
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  2. Patricia A. Gorman
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  3. Christine A. Kozak
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Krissansen, G.W., Gorman, P.A., Kozak, C.A. et al. Chromosomal locations of the gene coding for the CD3 (T3) γ subunit of the human and mouse CD3/T-cell antigen receptor complexes. Immunogenetics 26, 258–266 (1987). https://doi.org/10.1007/BF00346520

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