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Genetics of human S-adenosylhomocysteine hydrolase. A new polymorphism in man

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Summary

A specific staining procedure for the demonstration of S-adenosylhomocysteine hydrolase (SAAH, EC 3.3.1.1) is given. The enzyme has a broad tissue distribution and is also present in erythrocytes. The SAHH gene is polymorphic in the population of southwest Germany with two common alleles: SAHH *1=0.96 and SAHH *1=0.04. Family studies resulted in the expected segregation ratios. No evidence for close linkage with a total of 25 marker loci was found. But information from human mouse somatic-cell hybrids led to the localization of the SAHH gene to human chromosome 20, thereby confirming the findings of Hershfield and Francke (1982).

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References

  • Hershfield MS, Francke U (1982) The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20. Science 216:739–741

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Authors and Affiliations

  1. Institut für Humangenetik und Anthropologie der Universität Freiburg, Albertstr. 11, D-7800, Freiburg, Federal Republic of Germany

    S. Bissbort, K. Bender & T. F. Wienker

  2. Institut für Humangenetik der Universität Münster, Vesaliusweg 12-14, D-4400, Münster, Federal Republic of Germany

    K. H. Grzeschik

Authors
  1. S. Bissbort
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  2. K. Bender
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  3. T. F. Wienker
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  4. K. H. Grzeschik
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Dedicated to Professor Dr. P. E. Becker on the occasion of his 75th birthday

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Bissbort, S., Bender, K., Wienker, T.F. et al. Genetics of human S-adenosylhomocysteine hydrolase. A new polymorphism in man. Hum Genet 65, 68–71 (1983). https://doi.org/10.1007/BF00285031

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  • DOI: https://doi.org/10.1007/BF00285031

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