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Tactile-visual acquisition and reversal learning deficits in rats with prefrontal cortical lesions

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Summary

Rats with prefrontal cortex (PFC) lesions or sham operations were tested for acquisition and reversal learning with tactile-visual stimuli. PFC rats performed extremely poorly during acquisition and also differed from control rats in reversal learning. Both higher-order processing and subtle motoric dysfunctions may have combined to account for the marked effects of these cortex lesions.

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Author information

Authors and Affiliations

  1. Department of Psychology, Washington University, 63130, St. Louis, MO, USA

    B. Doar

  2. Department of Psychology and Program in Neural Sciences, Washington University, 63130, St. Louis, MO, USA

    S. Finger

  3. Departments of Anatomy and Neurobiology, Preventive Medicine and Psychology, Programs in Occupational Therapy and Neural Sciences, Washington University, School of Medicine, 63110, St. Louis, MO, USA

    C. R. Almli

Authors
  1. B. Doar
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  2. S. Finger
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  3. C. R. Almli
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Additional information

This project was supported in part by BRSG S07 RR07054-19 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, National Institute of Health

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Doar, B., Finger, S. & Almli, C.R. Tactile-visual acquisition and reversal learning deficits in rats with prefrontal cortical lesions. Exp Brain Res 66, 432–434 (1987). https://doi.org/10.1007/BF00243317

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  • DOI: https://doi.org/10.1007/BF00243317

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