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Somatotopical projections from the supplementary motor area to the red nucleus in the macaque monkey

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Abstract

Direct projections from the supplementary motor area (SMA) to the red nucleus were investigated in the Japanese monkey (Macaca fuscata). The anterograde tracer, horseradish peroxidase conjugated to wheat germ agglutinin (WGA-HRP), was injected into various regions of the SMA after intracortical microstimulation mapping. After WGA-HRP injection into the orofacial, forelimb, or hindlimb region of the SMA, anterogradely labeled axon terminals were found, respectively, in the medial, intermediate, or lateral portion of the parvocellular part of the red nucleus, bilaterally with an ipsilateral predominance. The results indicate the clear somatotopical arrangement of corticorubral projections from the SMA.

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References

  • Catman-Berrevoets CE, Kuypers HGJM, Lemon RN (1979) Cells of origin of the frontal projections to magnocellular and parvocellular red nucleus and superior colliculus in cynomolgus monkey. An HRP study. Neurosci Lett 12:41–46

    Google Scholar 

  • Fujii M, Kusama T (1984) Fixation of horseradish peroxidase reaction products with ammonium molybdate. Neurosci Res 1:153–156

    Google Scholar 

  • Hartmann-von Monakow K, Akert K, Künzle H (1979) Projections of precentral and premotor cortex to the red nucleus and other midbrain areas in Macaca fascicularis. Exp Brain Res 34:91–105

    Google Scholar 

  • Humphrey DR, Gold R, Reed DJ (1984) Sizes, laminar and topographic origins of cortical projections to the major divisions of the red nucleus in the monkey. J Comp Neurol 225:75–94

    Google Scholar 

  • Kuypers HGJM, Lawrence DG (1967) Cortical projections to the red nucleus and the brain stem in the rhesus monkey. Brain Res 4:151–188

    Article  CAS  PubMed  Google Scholar 

  • Luppino G, Matelli M, Camarda RM, Gallese V, Rizzolatti G (1991) Multiple representations of body movements in mesial area 6 and the adjacent cingulate cortex: an intracortical microstimulation study in the macaque monkey. J Comp Neurol 311:463–482

    CAS  PubMed  Google Scholar 

  • Luppino G, Matelli M, Camada R, Rizzolatti G (1993) Corticocortical connections of area F3 (SMA-proper) and area 6 (PreSMA) in the macaque monkey. J Comp Neurol 338:114–140

    Google Scholar 

  • Matsuzaka Y, Aizawa H, Tanji J (1992) A motor area rostral to the supplementary motor area (presupplementary motor area) in the monkey: neuronal activity during a learned motor task. J Neurophysiol 68:653–662

    CAS  PubMed  Google Scholar 

  • Mesulam M-M (1978) Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26:106–117

    CAS  PubMed  Google Scholar 

  • Mitz AR, Wise SP (1987) The somatotopic organization of the supplementary motor area: intracortical microstimulation mapping. J Neurosci 7:1010–1021

    CAS  PubMed  Google Scholar 

  • Oka H (1988) Functional organization of the parvocellular red nucleus in the cat. Behav Brain Res 28:233–240

    Google Scholar 

  • Tanji J (1994) The supplementary motor area in the cerebral cortex. Neurosci Res 19:251–268

    Google Scholar 

  • Ten Donkelaar HJ (1988) Evolution of the red nucleus and rubrospinal tract. Behav Brain Res 28:9–20

    Google Scholar 

  • Wiesendanger M, Wiesendanger R (1984) The supplementary motor area in the light of recent investigations. Exp Brain Res Suppl 9:382–392

    Google Scholar 

  • Wiesendanger R, Wiesendanger M (1985a) The thalamic connections with mesial area 6 (supplementary motor cortex) in the monkey (Macaca fascicularis). Exp Brain Res 59:91–104

    Google Scholar 

  • Wiesendanger R, Wiesendanger M (1985b) Cerebello-cortical linkage in the monkey as revealed by transcellular labeling ith the lectin wheat germ agglutinin conjugated to the marker horseradish peroxidase. Exp Brain Res 59:105–117

    Google Scholar 

  • Wise SP, Tanji J (1981) Supplementary and precentral motor cortex: contrast in responsiveness to peripheral input in the hindlimb area of the unanesthetized monkey. J Comp Neurol 195:433–451

    Google Scholar 

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Tokuno, H., Takada, M., Nambu, A. et al. Somatotopical projections from the supplementary motor area to the red nucleus in the macaque monkey. Exp Brain Res 106, 351–355 (1995). https://doi.org/10.1007/BF00241130

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