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Supraspinal facilitation of cutaneous polysynaptic EPSPs in cat medial gastrocnemius motoneurons

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Summary

We examined the characteristics of postsynaptic potentials (PSPs) produced in antidromically-identified medial gastrocnemius (MG) α-motoneurons by electrical stimulation of low threshold (< 3×T) distal limb cutaneous afferents in the sural (SUR) nerve in adult cats anesthetized with α-chloralose, together with the effects on SUR PSPs of supraspinal conditioning stimulation of the contralateral red nucleus (RN) and pyramidal tract (PT). In the majority of MG motoneurons, SUR afferents with electrical thresholds < 1.5×T produced early excitatory synaptic potentials (EPSPs) with minimum central latency of about 2.0 ms, suggesting activation of a trisynaptic segmental pathway with two interposed interneurons. Such early EPSPs were often detectable with stimuli < 1.2×T, as determined by recording the compound action potential in the sciatic nerve and from the first appearance of the N1 wave of the cord dorsum potential. Inhibitory synaptic potentials (IPSPs) were regularly produced by SUR volleys of only slightly greater strength (often as low as 1.3×T) and these had minimum central latencies of about 3.0 ms (about 1.0 ms longer than the earliest EPSPs), suggesting a three interneuron central pathway.

Repetitive stimulation of RN and PT regularly produced facilitation of both EPSP and IPSP components in the SUR response, suggesting that these supraspinal systems directly or indirectly excite some of the same interneurons that convey the SUR effects to MG motoneurons. When using very low strength SUR stimuli, PT conditioning produced relatively pure facilitation of the SUR EPSPs but with larger SUR volleys, PT clearly facilitated both EPSPs and IPSPs. RN conditioning produced more parallel facilitation of SUR EPSPs and IPSPs. Supraspinal control of the polysynaptic pathway producing SUR EPSPs is of particular interest because of earlier evidence that this pathway is differentially distributed to motoneurons of fast twitch versus slow twitch MG motor units.

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Author notes

  1. M. J. Pinter

    Present address: Dept. of Physiology, University of Göteborg, Göteborg, Sweden

  2. M. J. O'Donovan

    Present address: Dept. of Biology, Yale University, New Haven, CN, USA

  3. R. P. Dum

    Present address: Dept. of Neurosurgery, SUNY Upstate Medical Center, Syracuse, NY, USA

Authors and Affiliations

  1. Laboratory of Neural Control, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, 20205, Bethesda, MD, USA

    M. J. Pinter,  R. E. Burke, M. J. O'Donovan & R. P. Dum

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  1. M. J. Pinter
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  2. R. E. Burke
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  3. M. J. O'Donovan
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  4. R. P. Dum
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Additional information

Supported by USPHS Postdoctoral Fellowship 1F32NS 06131

Supported by Muscular Dystrophy Society of America Post-doctoral Fellowship

Supported by USPHS Postdoctoral Fellowship 1F32NS 05677

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Pinter, M.J., Burke, R.E., O'Donovan, M.J. et al. Supraspinal facilitation of cutaneous polysynaptic EPSPs in cat medial gastrocnemius motoneurons. Exp Brain Res 45, 133–143 (1982). https://doi.org/10.1007/BF00235772

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  • DOI: https://doi.org/10.1007/BF00235772

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