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Epidermal growth factor receptor: Elements of intracellular communication

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Summary

While EGF has an important function in cell growth regulation, the molecular mechanisms by which intracellular signal connect the EGF: receptor complex on the plasma membrane with the initiation of DNA synthesis and mitogenesis is not well understood. The discovery that rasGAP, PI-3 kinase and PLC-γ1 are substrates for the EGF receptor tyrosine kinase has provided a beginning in understanding the biochemistry underlying growth factor receptor transduction.

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  1. Department of Biochemistry, Vanderbilt University School of Medicine, 37232-0146, Nashville, Tennessee

    S. M. Teresa Hernández-Sotomayor

  2. Department of Medicine, Vanderbilt University School of Medicine, 37232-0146, Nashville, Tennessee

    Graham Carpenter

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  1. S. M. Teresa Hernández-Sotomayor
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The authors thank Suzanne Carpenter for preparation of the manuscript. S.M.T.H.-S. is a Fogarty International Research Fellow (TW 04600), and acknowledgement is given of research support from the National Cancer Institute (CA43720, CA24071).

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Hernández-Sotomayor, S.M.T., Carpenter, G. Epidermal growth factor receptor: Elements of intracellular communication. J. Membarin Biol. 128, 81–89 (1992). https://doi.org/10.1007/BF00231881

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