Influence of remote targets on directionality of striate neurons in rabbits

Summary

The described investigations study the influence of additional targets located well outside the classical receptive field on responses to motion of cortical cells in rabbits. Animals are anesthetized and prepared for acute single cells recordings in a conventional manner. The interactions between remote targets and central stimuli are abolished with microinjections of lidocaine hydrochloride or GABA at the site excited by remote stimuli. Results show that responses to motion of cortical cells are particularly sensitive to these manipulations. Although supplementary targets fail to influence spontaneous activity of all cells, they do influence responses to motion. Overall, the directionality indices (DI) declined. (53 to 45.) This decline may express itself either by a decrease of responses in the preferred direction or an enhancement of responses in the non-preferred direction or both. By contrast, responses to stationary stimuli are unaffected by additional targets in the visual field. Globally, cells whose directionality index was superior to 50% were significantly more affected then cells whose DI was less than 50%. This result suggests that similarly to cats, the directionality of cells in the striate cortex rests on a very fragile convergence of excitatory and inhibitory influences.