Skip to main content
SpringerLink
Log in

Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states

  • Review
  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Summary

The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5′, 5′′′-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Adair GM, Thompson LH, Fong S: Somat Cell Genet 5:329–344, 1979.

    Google Scholar 

  2. Airhart J, Vidrich A, Khairallah EA: Biochem J 140:539–548, 1974.

    Google Scholar 

  3. Altman K: Proc Natl Acad Sci, USA 69:3567–3569, 1972.

    Google Scholar 

  4. Andrulis IL, Hatfield GW, Arfin SM: J Biol Chem 254:10629–10633, 1979.

    Google Scholar 

  5. Arnett FC, Hirsch TJ, Bias WB, Nishikai M, Reichlin M: J Rheumatol 8:925–930, 1981.

    CAS  PubMed  Google Scholar 

  6. Bandyopadhyay AK, Deutscher MP: J Mol Biol 60:113–122, 1971.

    Google Scholar 

  7. Baril E, Bonin P, Burstein D, Mara K, Zamecnik P: Proc Natl Acad Sci, USA 80:4931–4935, 1983.

    Google Scholar 

  8. Berg BH: Biochem Biophys Acta 521:274–287, 1978.

    Google Scholar 

  9. Bernstein RM, Reichlin M, Hughes GRV Mathews MB: Arthritis Rheum 27:S66, 1984.

    Google Scholar 

  10. Blanquet S, Plateau P, Brevet A: Mol Cell Biochem 52:3–11, 1983.

    Google Scholar 

  11. Blazejowski CA, Webster GC: Mech Ageing Dev 21:343–356, 1983.

    Google Scholar 

  12. Brevet A, Plateau P, Cirakoglu B, Pailliez J-P, Blanquet S: J Biol Chem 257:14613–14615, 1982.

    Google Scholar 

  13. Cameselle JC, Costas MJ, Gunther S, Sillero A: J Biol Chem 259:2879–2885, 1984.

    Google Scholar 

  14. Carias JR, Mouricout M, Quintard B, Thomes JC, Julien R: Eur J Biochem 87:583–590, 1978.

    Google Scholar 

  15. Caston JD: Devel Biol 24:19–36, 1971.

    Google Scholar 

  16. Chamberlain JW, Pollard JW, Stanners CP: J Cell Biol 98:1603–1605, 1984.

    Google Scholar 

  17. Chavancy G, Garel J-P, Daillie J: FEBS Lett 49:380–384, 1975.

    Google Scholar 

  18. Chavancy G, Fournier A: Biochimie 61:229–243, 1979.

    Google Scholar 

  19. Christensen ML, Pachman LM, Maryjowski MC, Friedman JM: Arthritis Rheum 26:S524, 1983.

    Google Scholar 

  20. Ciechanover A, Wolin SL, Steitz JA, Lodish HF: Proc Natl Acad Sci, USA 82:1341–1345, 1985.

    Google Scholar 

  21. Cirakoglu B, Mirande M, Waller J-P: FEBS Lett 183:185–190, 1985.

    Google Scholar 

  22. Cirakoglu B, Waller J-P: Eur J Biochem 149:353–361, 1985.

    Google Scholar 

  23. Cirullo RE, Arredondo-Vega FX, Smith M, Wasmuth JJ: Somat Cell Mol Genet 10:225–234, 1983.

    Google Scholar 

  24. Cirullo RE, Wasmuth JJ: Somat Cell Mol Genet 10:225–234, 1984.

    Google Scholar 

  25. Colas B, Boulanger Y: FEBS Lett 163:175–180, 1983.

    Google Scholar 

  26. Cook JR, Buetow DE: Mech Ageing dev 17:41–52, 1981.

    Google Scholar 

  27. Creppy EE, Kern D, Steyn PS, Vlaeggar R, Roschenthaler R, Dirheimer G: Toxicol Lett 19:217–224, 1983.

    Google Scholar 

  28. Damuni Z, Caudwell FB, Cohen P: Eur J Biochem 129:57–65, 1982.

    Google Scholar 

  29. Dana S, Wasmuth JJ: Mol Cell Biol 2:1220–1228, 1982.

    Google Scholar 

  30. Dang CV, Yang DCH: J Biol Chem 254:5350–5356, 1979.

    Google Scholar 

  31. Dang CV, Yang DCH: Int J Biochem 14:539–543, 1982.

    Google Scholar 

  32. Dang CV, Johnson DL, Yang DCH: FEBS Lett 142:539–543, 1982.

    Google Scholar 

  33. Dang, CV, Mawhinney TP, Hilderman RH: Biochemistry 21:4891–4895, 1982.

    Google Scholar 

  34. Dang CV: Biochem Biophys Res Commun 106:44–47, 1982.

    Google Scholar 

  35. Dang CV, Yang DCH, Pollard TD: J Cell Biol 96:1138–1147, 1983.

    Google Scholar 

  36. Dang CV, Dang CV: Biochem Biophys Res Commun 117:464–469, 1983

    Google Scholar 

  37. Dang CV, Dang CV: Biosci Rep 3:527–538, 1983.

    Google Scholar 

  38. Dang CV, Dang CV: Mol Cell Biochem 63:131–136, 1984.

    Google Scholar 

  39. Dang CV: Cell Biol Int Rep 6:323–327, 1984.

    Google Scholar 

  40. Dang CV, LaDuca FM, Bell WR: Exp Cell Res 164:261–266, 1986.

    Google Scholar 

  41. Datta RK, Antopol W: Brain Res 53:373–388, 1973.

    Google Scholar 

  42. Datta RK, Antopol W: Naunyn Schmied Arch Pharmacol 280:107–111, 1973.

    Google Scholar 

  43. David ET, Fischer I, Moldave K: J Biol Chem 258:7702–7706, 1983.

    Google Scholar 

  44. Davies MR, Lambert LP, Marshall RD: Clin Sci 56:539–545, 1979.

    Google Scholar 

  45. Del Monte U, Cini G: FEBS Lett 20:33–36, 1972.

    Google Scholar 

  46. Del Monte U: Tumori 61:304–312, 1975.

    Google Scholar 

  47. Del Monte U, Perego R: Med Biol Environ (Brussels) 11:149–156, 1983.

    Google Scholar 

  48. Demidov SV, El'skaya AV: Ukr Biochim Zh 52:75–78, 1980.

    Google Scholar 

  49. Denney RM: Arch Biochem Biophys 183:157–167, 1977.

    Google Scholar 

  50. Denney RM, Borgaonkar D, Ruddle FH: Cytogenet Cell Genet 22:493–497, 1978.

    Google Scholar 

  51. Deutscher MP: J Cell Biol 99:373–377, 1984.

    Google Scholar 

  52. Diatewa M, Stahl AJC: Nucleic Acid Res 9:6293–6304, 1981.

    Google Scholar 

  53. Flaim KE, Peavy DE, Everson WV, Jefferson LS: J Biol Chem 257:2932–2938, 1982.

    Google Scholar 

  54. Fleming EW, Tewaii S, Noble EP: J neurochem 24:553–560, 1975.

    Google Scholar 

  55. Gabius HJ, Golbach S, Graupner G, Rehm S, Cramer F: Mech Ageing Dev 20:305–313, 1982.

    Google Scholar 

  56. Gabius HJ, Gabius S, Graupner G, Cramer F: Z Naturforsh 38c:881–882, 1983.

    Google Scholar 

  57. Gantt JS, Bennett CA, Arfin SM: Proc Natl Acad Sci, USA 78:5367–5370, 1981.

    Google Scholar 

  58. Gerken SC, Arfin SM: J Biol Chem 259:9202–9206, 1984.

    Google Scholar 

  59. Gibson K, Harris P: J Mol Cell Cardiol 4:381–390, 1972.

    Google Scholar 

  60. Gibson K, Harris P: J Mol Cell Cardiol 5:419–425, 1973.

    Google Scholar 

  61. Giles RE, Shimizu N, Ruddle FH: Somat Cell Genet 6:667–687, 1980.

    Google Scholar 

  62. Goerlich O, Foeckler R, Holler E: Eur J Biochem 126:135–142, 1982.

    Google Scholar 

  63. Graf H: Biochim Biophys Acta 425:175–181, 1976.

    Google Scholar 

  64. Grummt F, Weinmann-Dorsch C, Schneider-Schaulies J, Lux A: Exp Cell Res 163:191–120, 1986.

    Google Scholar 

  65. Gulik A, Orsini G: Mol Biol Rep 10:23–30, 1984.

    Google Scholar 

  66. Gunning PW, Por SB, Langford CJ, Scheffer JW, Austin L, Jeffrey PL: J Neurochem 32:1737–1743, 1979.

    Google Scholar 

  67. Hampel AE, Enger MD: J Mol Biol 79:285–293, 1973.

    Google Scholar 

  68. Harris JR: Micron Microscop Acta 14:193–205, 1983.

    Google Scholar 

  69. Hatfield D, Varricchio F, Rice M, Forget BG: J Biol Chem 257:3183–3188, 1982.

    Google Scholar 

  70. Hele P, Hebert L: Biochim Biophys Acta 479:311–321, 1977.

    Google Scholar 

  71. Hilderman RH: Biochemistry 22:4353–4357, 1983.

    Google Scholar 

  72. Ilan J, Singer M: J Mol Biol 91:39–51, 1975.

    Google Scholar 

  73. Joachimiak A, Barciszewski J: FEBS Lett 119:201–211, 1980.

    Google Scholar 

  74. Johnson DL, Dang CV, Yang DCH: J Biol Chem 255:4362–4366, 1980.

    Google Scholar 

  75. Johnson DL, Yang DCH: Proc Natl Acad Sci, USA 78:4059–4062, 1981.

    Google Scholar 

  76. Jones GH: Biochemistry 18:4542–4547, 1979.

    Google Scholar 

  77. Joshi S, Joshi RL, Haenni A-L, Chapeville F: Trends Biochem Sci 8:402–404, 1983.

    Google Scholar 

  78. Kellerman O, Tonetti H, Brevet A, Mirande M, Pailliez JP, Waller J-P: J Biol Chem 257:11041–11048, 1982.

    Google Scholar 

  79. Klekamp M, Pahuski E, Hampel A: Somat Cell Genet 7:725–735, 1981.

    Google Scholar 

  80. Klekamp M, Pahuski E, Hampel A: Biochemistry 21:3513–3517, 1982.

    Google Scholar 

  81. Kisselev LL, Favorova OO: Adv Enzymol Mol Biol 40:141–238, 1974.

    Google Scholar 

  82. Kushner JP, Boll D, Quaqliana J, Dickman S: Proc Soc Exp Biol Med 153:273–276, 1976.

    Google Scholar 

  83. Laidlaw SA, Moldave K: J Biol Chem 255:11908–11913, 1980.

    Google Scholar 

  84. Lamkin AF, Smith DW, Hurlbert R: Biochemistry 12:4137–4145, 1973.

    Google Scholar 

  85. Lobaton CD, Moreno A, Oxender DL: Mol Cell Biol 4:475–483, 1984.

    Google Scholar 

  86. Lodemann E: Biochem Biophys Res Commun 102:775–783, 1981.

    Google Scholar 

  87. Lofgren DJ, Thompson LH: J Cell Physiol 99:303–312, 1979.

    Google Scholar 

  88. Margalioth EJ, Schenker JG, Chevion M: Cancer 52:868–871, 1983.

    Google Scholar 

  89. Mathews MB, Bernstein RM: Nature (London) 304:177–179, 1983.

    Google Scholar 

  90. Mathews MB, Reichlin M, Hughes GRV, Bernstein RM: J Exp Med 160:420–434, 1984.

    Google Scholar 

  91. McCune SA: Acta Genet Med Gemmellol (Roma) 26:21–27, 1977.

    Google Scholar 

  92. McCune SA, Morris HP, Weber G: Biochim Biophys Acta 561:410–420, 1979.

    Google Scholar 

  93. McKusick VA: J Heredity 71:370–391, 1980.

    Google Scholar 

  94. McNurlan MA, Tomkins AM, Garlick PJ: Biochem J 178:373–379, 1979.

    Google Scholar 

  95. Mirande M, Cirakoglu B, Waller J-P: Eur J Biochem 131:163–170, 1983.

    Google Scholar 

  96. Mirande M, LeCorre D, Louvard D, Reggio H, Pailliez JP, Waller J-P: Exp Cell Res 156:91–102, 1985.

    Google Scholar 

  97. Mirande M, LeCorre D, Waller J-P: Eur J Biochem 147:281–289, 1985.

    Google Scholar 

  98. Moore PA, Jayme DW, Oxender DL: J Biol Chem 252:7427–7430, 1977.

    Google Scholar 

  99. Neidhardt FC, Parker J, McKeever W: Ann Rev Microbiol 109:7–12, 1975.

    Google Scholar 

  100. Nielsen JB, Hashmeyer AEV: Biochemistry 15:348–355, 1976.

    Google Scholar 

  101. Nishikai M, Reichlin M: Arthritis Rheum 23:881–888, 1980.

    Google Scholar 

  102. Nowak TS, Jr, Munro HN: Biochem Biophys Res Commun 225:722–730, 1977.

    Google Scholar 

  103. Nowak TS, Albright EB, Munro HN: Arch Biochem Biophys 225:722–730, 1983.

    Google Scholar 

  104. Ofengand J: in Perez-Berkoff R (ed), Protein Biosynthesis in Eukaryotes. Plenum Press, New York, 1982, 1–67

    Google Scholar 

  105. Olgivie A, Huschka U, Kersten W: Biochim Biophys Acta 565:293–304, 1979.

    Google Scholar 

  106. Okada N, Mukai R, Hrada F, Kabashima T, Nakao Y, Yamane K, Oshima Y, Sakamoto K, Itoh M, Kashiwagi H, Yamaguchi H: Eur J Biochem 139:425–429, 1984.

    Google Scholar 

  107. Orlovskaya NN, Veselovskaya LD, Gulyi MF: Ukr Biochim Zh 52:325–328, 1980.

    Google Scholar 

  108. Osterman LA: Biochimie 61:323–342, 1979.

    Google Scholar 

  109. Pahuski E, Klekamp M, Codon T, Hampel AE: J Cell Physiol 114:82–87, 1983.

    Google Scholar 

  110. Perego R, Del Monte U: IRCS Med Sci 10:536–537, 1982.

    Google Scholar 

  111. Pohlreich P, Hradec J: Biochem Biophys Res Commun 113:868–875, 1983.

    Google Scholar 

  112. Pollard JW, Lam T, Stanners CP: J Cell Physiol 105:313–325, 1980.

    Google Scholar 

  113. Putney SD, Schimmel P: Nature (London) 291:632–635, 1981.

    Google Scholar 

  114. Quelette AT, Taylor MW: Cancer Res 34:1636–1642, 1974.

    Google Scholar 

  115. Rapport E, Zamecnik PC: Proc Natl Acad Sci, USA 11:3984–3988, 1976.

    Google Scholar 

  116. Rapaport E, Zamecnik PC, Baril EF: Proc Natl Acad Sci, USA 78:838–842, 1981.

    Google Scholar 

  117. Reedy DB, Boak AM, Zwillich SM, Agris PF: Arthritis Rheum 27:829, 1984.

    Google Scholar 

  118. Reichlin M, Arnett FC: Arthritis Rheum 27:1150–1156, 1984.

    Google Scholar 

  119. Ritter P, Enger MD, Hampel AE: in Fishman WH, Sell SS (eds), Onco-developmental Gene Expression. Academic Press, New York, 1976, 47–56.

    Google Scholar 

  120. Robert-Gero M, Lawrence F, Vigier P: Cancer Res 35:3571–3576, 1975.

    Google Scholar 

  121. Rosa MD, Hendrick JP, Lerner MR, Steitz J, Reichlin M: Nucleic Acid Res 11:853–870, 1983.

    Google Scholar 

  122. Rubnitz JE, Jacobsen SJ, Hoffman RM: Biochim Biophys Acta 677:269–273, 1981.

    Google Scholar 

  123. Ryazanov AG: FEBS Lett 178:6–9, 1984.

    Google Scholar 

  124. Salomon R, Littauer UZ: Nature (London) 249:32–34, 1974.

    Google Scholar 

  125. Sambuy Y, Bittles AH: Mech Ageing Dev 20:279–287, 1982.

    Google Scholar 

  126. Sato A, Noda K, Natori Y: Biochim Biophys Acta 561:475–483, 1979.

    Google Scholar 

  127. Scheffer JW, Howe N, Gunning PW, Austin L: J Neurochem 42:698–704, 1984.

    Google Scholar 

  128. Schimmel PR, Söll D: Ann Rev Biochem 48:601–648, 1979.

    Google Scholar 

  129. Schmid HP, Akhayat O, DeSa CM, Puvion F, Koehler K, Scherrer K: EMBO J 3:29–34, 1984.

    Google Scholar 

  130. Schreiber SS, Evans CD, Oratz M, Rothschild: Circulation Res 48:601–611, 1981.

    Google Scholar 

  131. Scornik OA, Ledbetter MLS, Malter JS: J Biol Chem 255:6322–6329, 1980.

    Google Scholar 

  132. Scornik OA: J Biol Chem 258:882–886, 1983.

    Google Scholar 

  133. Shenoy ST, Rogers QR: Biochim Biophys Acta 476:218–227, 1977.

    Google Scholar 

  134. Shotwell MA, Mattes PM, Jayme DW, Oxender DL: J Biol Chem 257:2974–2980, 1982.

    Google Scholar 

  135. Shotwell MA, Collarini EJ, Mansukhani A, Hampel AE, Oxender DL: J Biol Chem 258:8183–8187, 1983.

    Google Scholar 

  136. Sihag RK, Deutscher MP: J Biol Chem 258:11846–11850, 1983.

    Google Scholar 

  137. Smith DW, Silbert PE, McNamara AL: Biochim Biophys Acta 562:453–461, 1979.

    Google Scholar 

  138. Som K, Hardesty B: Arch Biochem Biophys 166:507–517, 1975.

    Google Scholar 

  139. Souciet G, Dietrich A, Colas B, Razafimanatra P, Weil JH: J Biol Chem 257:9598–9604, 1982.

    Google Scholar 

  140. Stanners CP, Wightman TM, Harkins JL: J Cell Physiol 95:125–138, 1978.

    Google Scholar 

  141. Strehler BL, Hendley DD, Hirsch GP: Proc Natl Acad Sci, USA 57:1751–1758, 1967.

    Google Scholar 

  142. Strongwater SL, Dorovini-Zis K, Ball RD, Schnitzer TJ: Arthritis Rheum 27:433–442, 1984.

    Google Scholar 

  143. Tanaka WK, Som K, Hardesty B: Arch Biochem Biophys 172:252–260, 1976.

    Google Scholar 

  144. Taudou G, Wiart J, Panijel J: Mol Immun 18:245–248.

  145. Taudou G, Wiart J, Panijel J: Mol Immun 20:255–261, 1983.

    Google Scholar 

  146. Thompson LH, Lofgren DJ, Adair GM: Cell 11:157–168, 1977.

    Google Scholar 

  147. Turovskij VS: Biokhimiia 44:1502–1505, 1980.

    Google Scholar 

  148. Usatenko MS, Teslenko LV: Biokhimiia 43:2196–2199, 1978.

    Google Scholar 

  149. Ussery MA, Tanaka WK, Hardesty B: Eur J Biochem 72:491–500, 1977.

    Google Scholar 

  150. Vadeboncoeur C, Lapointe J: Brain Res 188:129–138, 1980.

    Google Scholar 

  151. Vadeboncoeur C, Lapointe J: Eur J Biochem 109:581–587, 1980.

    Google Scholar 

  152. Varshavsky A: Cell 34:711–712, 1983.

    Google Scholar 

  153. Varshavsky A: J Theor Biol 105:707–714, 1983.

    Google Scholar 

  154. Vennegoor C, Blomendal H: Eur J Biochem 26:462–473, 1972.

    Google Scholar 

  155. Wagner G, Uterreiner AM: Chem Biol Int 37:233–244, 1981.

    Google Scholar 

  156. Wahab SZ, Yang DCH: J Biol Chem 260:5286–5289, 1985.

    Google Scholar 

  157. Walker EJ, Treacy B, Jeffrey PD: Biochemistry 22:1934–1941, 1983.

    Google Scholar 

  158. Walter P, Gangloff J, Bonnet J, Boulanger Y, Ebel J-P Fasiolo F: Proc Natl Acad Sci, USA 80:2437–2441, 1983.

    Google Scholar 

  159. Weber G: New Engl J Med 296:486–493, 541–551, 1977.

    Google Scholar 

  160. Weinmann-Dorsch C, Hedl A, Grummt I, Albert W, Ferdinand F-J, Friis RR, Pierron G, Moll W, Grummt F: Eur J Biochem 138:179–185, 1984.

    Google Scholar 

  161. Wilson MJ, Hatfield DL, Poirer LA: FEBS Lett 128:157–160, 1981.

    Google Scholar 

  162. Wright HT, Nurse KC, Golstein DJ: Science 213:455–456, 1981.

    Google Scholar 

  163. Yang DCH, Dang CV, Arnett FC: Biochem Biophys Res Commun 120:15–21, 1984.

    Google Scholar 

  164. Yaremchuk AD, El'skaya AV: Ukr Biokhim Zh 55:363–367, 1983.

    Google Scholar 

  165. Yoshida S, Akizuki M, Mimori T, Yamagata H, Inada S, Homma M: Arthritis Rheum 26:604–611, 1983.

    Google Scholar 

  166. Zamecnik P: Anal Biochem 134:1–10, 1983.

    Google Scholar 

  167. Zgorzalewicz B: Biol Neonate 23:161–170, 1983.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of California, 92521, Riverside, CA

    Chuan V. Dang & Chi V. Dang

  2. Cancer Research Institute, University of California, Moffitt 1282, 94143, San Francisco, CA, USA

    Chuan V. Dang & Chi V. Dang

Authors
  1. Chuan V. Dang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chi V. Dang
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dang, C.V., Dang, C.V. Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states. Mol Cell Biochem 71, 107–120 (1986). https://doi.org/10.1007/BF00214769

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00214769

Keywords

Search

Navigation