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Type C viruses: Natural derivatives of cellular genes involved in malignant transformation

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References

  1. Barbacid, M., Troxler, D., Scolnick, E. M., Aaronson, S. A.: Analysis of translational products of Friend strain of spleen focus-forming virus. J. Virol. 27, 826 (1978)

    Google Scholar 

  2. Benveniste, R. E., Todaro, G. J.: Multiple divergent copies of endogenous C-type virogenes in mammalian cells. Nature 252, 170 (1974)

    Google Scholar 

  3. Berns, A., Jaenisch, R.: Increase of AKR-specific sequences in the tissues of leukemic AKR mice. Proc. Natl. Acad. Sci. USA 73, 2448 (1976)

    Google Scholar 

  4. Bister, K., Hayman, M. J., Vogt, P. K.: Defectiveness of avian myeloblastosis virus MC29: isolation of long-term nonproducer cultures and analysis of virus-specific polypeptide synthesis. Virology 82, 431 (1977)

    Google Scholar 

  5. Brugge, J. S., Erikson, R. L.: Identification of a transformation-specific antigen induced by an avian sarcoma virus. Nature 269, 346 (1977)

    Google Scholar 

  6. Coffin, J. M., Haseltine, W. A.: Terminal redundancy and the origin of replication of Rous sarcoma virus RNA. Proc. Natl. Acad. Sci. USA 74, 1908 (1977)

    Google Scholar 

  7. Cohen, J. C., Shank, P. R., Morris, V. M., Cardiff, R., Varmus, H. E.: Integration of mouse mammary tumor virus DNA in infected mammary glands and tumors of the mouse. Cell. 16, 333 (1979)

    Google Scholar 

  8. Collett, M. S., Erikson, R. L.: Protein kinase activity associated with the avian sarcoma virus src gene product. Proc. Natl. Acad. Sci. USA 75, 2021 (1978)

    Google Scholar 

  9. DeLarco, J., Rapp, U., Todaro, G. J.: Cell surface receptors for ecotropic MuLV: detection and tissue distribution of free receptors in vivo. Int. J. Cancer 21, 356 (1978)

    Google Scholar 

  10. DeLarco, J., Todaro, G. J.: Membrane receptors for murine leukemia viruses: characterization using the purified envelope glycoprotein, gp71. Cell, 8, 365 (1976)

    Google Scholar 

  11. DeLarco, J. E., Todaro, G. J.: Growth factors from murine sarcoma virus-transformed cells. Proc. Natl. Acad. Sci. USA 75, 4001 (1978)

    Google Scholar 

  12. Duesberg, P. H., Wang, L. H., Mellon, P., Mason, W. S., Vogt, P. K.: Towards a complete genetic map of Rous sarcoma virus. In: ICN-UCLA Symposium on Molecular and Cellular Biology, Baltimore, D., Huang, A. S., Fox, C. F. eds., Vol. 4. p. 107. New York: Academic Press 1976

    Google Scholar 

  13. Essex, M.: Horizontally and vertically transmitted oncornaviruses of cats. Adv. Cancer Res. 21, 175 (1975)

    Google Scholar 

  14. Fischinger, P. J., Blevins, C., Dunlop, N. M.: Genomic masking of nondefective recombinant murine leukemia virus in Moloney virus stocks. Science 201, 457 (1978)

    Google Scholar 

  15. Frankel, A. E., Fischinger, P. J.: Nucleotide sequences in mouse DNA and RNA specific for Moloney sarcoma virus. Proc. Natl. Acad. Sci. USA 73, 3705 (1976)

    Google Scholar 

  16. Frankel, A. E., Fischinger, P. J.: Rate of divergence of cellular sequences homologous to segments of Moloney sarcoma virus. J. Virol. 21, 153 (1977)

    Google Scholar 

  17. Frankel, A. E., Newbauer, R. L., Fischinger, P. J.: Fractionation of DNA nucleotide transcripts from Moloney sarcoma virus and isolation of sarcoma virus-specific complementary DNA. J. Virol. 18, 481 (1976)

    Google Scholar 

  18. Furth, J.: Prolongation of life with prevention of leukemia by thymectomy in mice. J. Gerontol. 1, 46 (1946)

    Google Scholar 

  19. Gazdar, A. F., Oie, H., Lalley, P., Moss, W. W., Minna, J. D.: Identification of mouse chromosomes required for murine leukemia virus replication. Cell 11, 949 (1977)

    Google Scholar 

  20. Gazdar, A. F., Russel, E. K., Minna, J. D.: Replication of mouse-tropic and xenotropic strains of murine leukemia virus in human X mouse hybrid cells. Proc. Natl. Acad. Sci. USA 71, 2642 (1974)

    Google Scholar 

  21. Graf, T., Beug, H.: Avian leukemia viruses: interaction with their target cells in vivo and in vitro. Biochem. Biophys. Acta 516, 269 (1978)

    Google Scholar 

  22. Gross, L.: Biological and pathogenic properties of a mouse leukemia virus. Acta Hematol. (Basel) 23, 259 (1960)

    Google Scholar 

  23. Gross, L.: Facts and theories on viruses causing cancer and leukemia. Proc. Natl. Acad. Sci. USA 71, 2013 (1974)

    Google Scholar 

  24. Guntaka, R. V., Richards, O. C., Shank, P. R., Kung, H. J., Davidson N., Fritsch, E., Bishop, J. M., Varmus, H. E.: Covalently closed circular DNA of avian sarcoma virus: Purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. J. Mol. Biol. 116, 337 (1976)

    Google Scholar 

  25. Hanafusa, H.: Cell transformation by RNA tumor viruses. Compr. Virol. 10, 401 (1977)

    Google Scholar 

  26. Hartley, J. W., Rowe, W. P.: Production of altered cell foci in tissue culture by defective Moloney sarcoma virus particles. Proc. Natl. Acad. Sci. USA 55, 780 (1966)

    Google Scholar 

  27. Hartley, J. W., Wolford, N. K., Old, L. J., Rowe, W. P.: A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc. Natl. Acad. Sci. USA 74, 789 (1977)

    Google Scholar 

  28. Haseltine, W. A., Maxam, A. M., Gilbert, W.: Rous sarcoma virus is terminally redundant: the 5′ sequence. Proc. Natl. Acad. Sci. USA 74, 989 (1977)

    Google Scholar 

  29. Haywood, W. S.: Size and genetic content of viral RNAs in avian oncovirus-infected cells. J. Virol. 24, 47 (1977)

    Google Scholar 

  30. Hsu, T., Sabran, J. L., Mark, G., Guntaka, R. V., Taylor, J. M.: Analysis of unintegrated avian tumor virus double-stranded DNA intermediates. J. Virol. 28, 810 (1978)

    Google Scholar 

  31. Huebner, R. J., Gilden, R. V., Toni, R., Hill. R. W., Trimmer, R. W., Fish, D. C., Sass, B.: Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes. Proc. Natl. Acad. Sci. USA 73, 4633 (1976)

    Google Scholar 

  32. Huebner, R. J., Hartley, J. W., Rowe, W. P., Lane, W. T., Capps, W. I.: Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses. Proc. Natl. Acad. Sci. USA 56, 1154 (1964)

    Google Scholar 

  33. Huebner, R. J., Todaro, G. J.: Oncogenes of RNA tumor viruses as determinants of cancer. Proc. Natl. Acad. Sci. USA 64, 1087 (1969)

    Google Scholar 

  34. Ihle, J. N., Domotor, J. J., Bengali, K. M.: Characterization of the type and group specificities of the immune response in mice to murine leukemia viruses. J. Virol. 18, 124 (1976)

    Google Scholar 

  35. Ihle, J., Hanna, M. G., Robertson, L. E., Kenney, F. T.: Autogenous immunity to endogenous RNA tumor virus: identification of antibody reacting to select viral antigens. J. Exp. Med. 136, 1568 (1974)

    Google Scholar 

  36. Jaenisch, R.: Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc. Natl. Acad. Sci. USA 73, 1260 (1976)

    Google Scholar 

  37. Jaenisch, R.: Germ line integration of Moloney leukemia virus: effect of homozygosity at the M-MuLV locus. Cell 12, 691 (1977)

    Google Scholar 

  38. Jaenisch, R., Fan, H., Croker, B.: Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal. Proc. Natl. Acad. Sci. USA 72, 4008 (1975)

    Google Scholar 

  39. Jamjoom, G. A., Arlinghaus, R. B.: Further characterization of intracellular precursor polyproteins of Rauscher leukemia virus. Virology 78, 11 (1977)

    Google Scholar 

  40. Joho, R. G., Stoll, E., Friis, R. R., Billeter, M. A., Weissman, C.: A partial genetic map of Rous sarcoma virus: location of polymerase, envelope and transformation markers. In: ICN-UCLA Symposium on Molecular and Cellular Biology, Baltimore, D., Huang, A. S., Fox, C. F., eds., p. 127. New York: Academic Press 1976

    Google Scholar 

  41. Kaplan, H. S.: On the natural history of the murine leukemias: Presidential address. Cancer Res. 27, 1325 (1967)

    Google Scholar 

  42. Kaplan, H. S.: Leukemia and lymphoma in experimental and domestic animals. Ser. Haemat. 7, 2 (1974)

    Google Scholar 

  43. Kawai, S., Duesberg, P. H., Hanafusa, H.: Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length. J. Virol. 24, 910 (1977)

    Google Scholar 

  44. Kerr, I. M., Olshevsky, U., Lodish, H. F., Baltimore, D.: Translation of murine leukemia virus RNA in cell free systems from animal cells. J. Virol. 18, 627 (1976)

    Google Scholar 

  45. Keshet, E., Temin, H. M.: Sites of integration of reticuloendotheliosis virus DNA in chicken DNA. Proc. Natl. Acad. Sci. USA. In press

  46. Khoury, A. T., Hanafusa, H.: Synthesis and integration of viral DNA in chicken cells at different times after infection with various multiplicities of avian oncornavirus. J. Virol. 18, 383 (1976)

    Google Scholar 

  47. Lee, J. C., Ihle, J. N., Huebner, R.: The humoral immune response of NIH Swiss and SWR/J mice to vaccination with formalinized AKR or Gross murine leukemia virus. Proc. Natl. Acad. Sci. USA 74, 343 (1977)

    Google Scholar 

  48. Lee, L. S., Weinstein, I. B.: Tumor-promoting phorbol esters inhibit binding of epidermal growth factor to cellular receptors. Science 202, 313 (1978)

    Google Scholar 

  49. Lemons, R. S., Nash, W. G., O'Brien, S. J., Benveniste, R. E., Sherr, C. J.: A gene (Bevi) on human chromosome six is an integration site for baboon type C provirus in human cells. Cell 14, 945 (1978)

    Google Scholar 

  50. Lemons, R. S., O'Brien, S. J., Sherr, C. J.: A new genetic locus, Bevi, on human chromosome six which controls the replication of baboon type C virus in human cells. Cell 12, 251 (1977)

    Google Scholar 

  51. Levinson, A. D., Opperman, H., Levintow, L., Varmus, H. E., Bishop, J. M.: Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell 15, 561 (1978)

    Google Scholar 

  52. Levy, J. A., Ihle, J. N., Oleszko, O., Barnes, R. D.: Virus specific neutralization by a soluble nonimmunoglobulin factor found naturally in normal mouse sera. Proc. Natl. Acad. Sci. USA 72, 5071 (1975)

    Google Scholar 

  53. McClintock, B.: The control of gene action in maize. Brookhaven Symp. Biol. 18, 162 (1965)

    Google Scholar 

  54. Mellon, P., Pawson, A., Bister, K., Martin, G. S., Duesberg, P.: Specific RNA sequences and gene products of MC29 avian acute leukemia virus. Proc. Natl. Acad. Sci. USA 75, 5874 (1978)

    Google Scholar 

  55. Miao, R., Fieldsteel, A. H., Fodge, D. W.: Opposing effects of tumor promoters on erythroid differentiation. Nature 274, 271 (1978)

    Google Scholar 

  56. Mueller-Lantzsch, N., Fan, H.: Monospecific immunoprecipitation of murine leukemia virus polyribosomes: identification of p30 protein specific messenger RNA. Cell 9, 579 (1976)

    Google Scholar 

  57. Murphy, E. C., Kopchick, J. J., Watson, K. F., Arlinghaus, R. B.: Cell-free synthesis of a precursor polyprotein containing both gag and pol gene products by Rauscher murine leukemia virus 35S RNA. Cell 13, 359 (1978)

    Google Scholar 

  58. O'Brien, S. J., Simonson, J. M.: Bvr-1, a restriction locus of type C RNA virus in the feline cellular genome: pleiotropic restriction of endogenous BALB virus in cat x mouse hybrid cells. J. Exp. Med. 147, 219 (1978)

    Google Scholar 

  59. Paterson, B. M., Marciani, D. J., Papas, T. S.: Cell-free synthesis of a precursor polypeptide for avian myeloblastosis virus DNA polymerase. Proc. Natl. Acad. Sci. USA 241, 4951 (1977)

    Google Scholar 

  60. Purchio, A. F., Erikson, E., Brugge, J., Erikson, R.: Identification of a polypeptide encoded by the avian sarcoma virus src gene. Proc. Natl. Acad. Sci. USA 75, 1567 (1978)

    Google Scholar 

  61. Purchio, A. F., Erikson, E., Erikson, R. L.: Translation of 35S and of subgenomic regions of avian sarcoma virus mRNA. Proc. Natl. Acad. Sci. USA 74, 4661 (1977)

    Google Scholar 

  62. Rapp, U., Todaro, G. J.: Generation of oncogenic type C viruses: Rapid leukemia viruses from C3H mouse cells derived in vitro and in vivo. Proc. Natl. Acad. Sci. USA 75, 1647 (1978)

    Google Scholar 

  63. Reynolds, R. K., VandeVen, W. J. M., Stephenson, J. R.: Translation of type C viral RNAs in Xenopus laevis oocytes: evidence that the 120 000 molecular weight polyprotein expressed in Abelson leukemia virus-transformed cells is virus coded. J. Virol. 28, 665 (1978)

    Google Scholar 

  64. Rothenberg, E., Donoghue, D. J., Baltimore, D.: Analysis of a 5′ leader sequence on murine leukemia virus 21S RNA: heteroduplex mapping with long reverse transcriptase products. Cell 13, 435 (1978)

    Google Scholar 

  65. Rothenberg, E., Smotkin, D., Baltimore, D., Weinberg, R. A.: In vitro synthesis of infections DNA of murine leukemia virus. Nature 269, 122 (1977)

    Google Scholar 

  66. Scolnick, E. M., Howk, R. S., Anisowicz, A., Peebles, P., Scher, C., Parks, W.: Separation of sarcoma virus-specific and leukemia virus-specific genetic sequences of Moloney sarcoma virus. Proc. Natl. Acad. Sci. USA 72, 4650 (1975)

    Google Scholar 

  67. Scolnick, E. M., Parks, W. P.: Harvey sarcoma virus: a second murine type C sarcoma virus with rat genetic information. J. Virol. 13, 1211 (1974)

    Google Scholar 

  68. Scolnick, E. M., Rands, E., Williams, D., Parks, W. P.: Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus. J. Virol. 12, 458 (1973)

    Google Scholar 

  69. Sheiness, D., Fanshier, L., Bishop, J. M.: Identification of nucleotide sequences which may encode the oncogenic capacity of avian retrovirus MC29. J. Virol. 28, 600 (1978)

    Google Scholar 

  70. Sherr, C. J., Sen, A., Todaro, G. J., Sliski, A., Essex, M.: Pseudotypes of feline sarcoma virus particles contain a 85 000 dalton protein with p15, p12 and feline oncornavirus-associated cell membrane antigen (FOCMA) activity. Proc. Natl. Cancer Inst. USA 75, 1505 (1978)

    Google Scholar 

  71. Sherr, C. J., Todaro, G. J., Sliski, A., Essex, M.: Characterization of a feline sarcoma virus-coded antigen (FOCMA-S) by radioimmunoassay. Proc. Natl. Acad. Sci. USA 75, 4489 (1978)

    Google Scholar 

  72. Sliski, A., Essex, M., Meyer, C., Todaro, G. J.: Feline oncornavirus associated cell membrane antigen: expression in transformed nonproducer mink cells. Science 196, 1336 (1977)

    Google Scholar 

  73. Staal, S. P., Hartley, J. W., Rowe, W. P.: Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proc. Natl. Acad. Sci. USA 74, 3065 (1977)

    Google Scholar 

  74. Stacey, D. W., Allfrey, V. G., Hanafusa, H.: Microinjection analysis of envelope glycoprotein messenger activities of avian leukosis viral RNAs. Proc. Natl. Acad. Sci. USA 74, 1614 (1977)

    Google Scholar 

  75. Stehelin, D., Guntaka, R. V., Varmus, H. E., Bishop, J. M.: Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. J. Mol. Biol. 101, 349 (1976)

    Google Scholar 

  76. Stehelin, D., Varmus, H. E., Bishop, J. M., Vogt, P. K.: DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature 260, 170 (1976)

    Google Scholar 

  77. Stephenson, J. R., Khan, A. S., Sliski, A. H., Essex, M.: Feline oncornavirus-associated cell membrane antigen: evidence for an immunologically crossreactive feline sarcoma virus-coded protein. Proc. Natl. Acad. Sci. USA 74, 5608 (1977)

    Google Scholar 

  78. Sveda, M. M., Fields, B. N., Soeiro, R.: Host restriction of Friend leukemia virus: fate of input virion RNA. Cell 2, 271 (1974)

    Google Scholar 

  79. Taylor, J. M.: An analysis of the role of tRNA species as primers for the transcription into DNA of RNA tumor virus genomes. Biochim. Biophys. Acta 473, 57 (1977)

    Google Scholar 

  80. Temin, H. M.: Mechanisms of cell transformation by RNA tumor viruses. Annu. Rev. Microbiol. 25, 609 (1971)

    Google Scholar 

  81. Temin, H. M., Baltimore, D.: RNA-directed DNA synthesis and RNA tumor viruses. Adv. Virus Res. 17, 129 (1972)

    Google Scholar 

  82. Todaro, G. J., Benveniste, R. E., Callahan, R., Lieber, M. M., Sherr, C. J.: Endogenous primate and feline type C viruses. Cold Spring Harbor Symp. Quant. Biol. 39, 1159 (1974)

    Google Scholar 

  83. Todaro, G. J., DeLarco, J. E., Cohen, S.: Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells. Nature 264, 26 (1976)

    Google Scholar 

  84. Todaro, G. J., DeLarco, J. E., Nissley, S. P., Rechler, M. M.: MSA and EGF receptors on sarcoma virus transformed cells and human fibrosarcoma cells in culture. Nature 267, 526 (1977)

    Google Scholar 

  85. Todaro, G. J., Sporn, M., DeLarco, J.: Retinoids block phenotypic cell transformation produced by sarcoma growth factor. Nature 276, 272 (1978)

    Google Scholar 

  86. Troxler, D. H., Boyars, J. K., Parks, W. P., Scolnick, E. M.: Friend strain of spleen focus forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus. J. Virol. 22, 361 (1977)

    Google Scholar 

  87. Varmus, H. E., Bishop, J. M., Vogt, P. K.: Appearance of virus-specific DNA in mammalian cells following transformation by Rous sarcoma virus. J. Mol. Biol. 74, 613 (1973)

    Google Scholar 

  88. Varmus, H. E., Heasly, S., Kung, H. J., Opperman, H., Smith, V. C., Bishop, J. M., Shank, P. R.: Kinetics of synthesis, structure and purification of avian sarcoma virus-specific DNA made in the cytoplasm of acutely infected cells. J. Mol. Biol. 120, 55 (1978)

    Google Scholar 

  89. Verma, I. M.: The reverse transcriptase. Biochim. Biophys, Acta 473, 1 (1977)

    Google Scholar 

  90. Vogt, P. K.: The genetics of RNA tumor viruses. Compr. Virol. 9, 341 (1977)

    Google Scholar 

  91. Vogt, P. K., Hu, S.: The genetic structure of RNA tumor viruses. Annu. Rev. Genet. 11, 203 (1977)

    Google Scholar 

  92. Vogt, V. M., Eisenman, R., Diggelman, H.: Generation of avian myeloblastosis virus structural proteins by proteolytic cleavage of a precursor polypeptide. J. Mol. Biol. 96, 471 (1975)

    Google Scholar 

  93. Von der Helm, K., Duesberg, P. H.: Translation of Rous sarcoma virus RNA in a cell-free system from Ascites Krebs II cells. Proc. Natl. Acad. Sci. USA 72, 614 (1975)

    Google Scholar 

  94. Weinberg, R. A.: Structure of the intermediates leading to the integrated provirus. Biochim. Biophys. Acta 473, 39 (1977)

    Google Scholar 

  95. Weiss, S. R., Varmus, H. E., Bishop, J. M.: The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukemia viruses. Cell 12, 983 (1977)

    Google Scholar 

  96. Witte, O. N., Rosenberg, N., Paskind, M., Shields, A., Baltimore, D.: Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblasts and lymphoid cells. Proc. Natl. Acad. Sci. USA 75, 2488 (1978)

    Google Scholar 

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  1. Laboratory of Viral Carcinogenesis, National Institutes of Health, National Cancer Institute, 20014, Bethesda, Maryland, USA

    Charles J. Sherr & George J. Todaro

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Sherr, C.J., Todaro, G.J. Type C viruses: Natural derivatives of cellular genes involved in malignant transformation. Springer Semin Immunopathol 2, 339–353 (1979). https://doi.org/10.1007/BF00198723

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