Skip to main content
SpringerLink
Log in

The effect of diphenylhydantoin on the electroretinogram

  • Published:
Documenta Ophthalmologica Aims and scope Submit manuscript

Abstract

Acute administration of diphenylhydantoin (DPH) in rabbits produces a significant increase in the amplitude of the a-wave. A marked increase in the amplitude of the b-wave is also noted but the time course is slower than that for the a-wave. While in controls the oscillatory potential (OP) recordings essentially consist of three major types, recordings taken after DPH injection consist of one major OP (OP2), which appears to be a result of the fusion of the original OP2 with another OP produced by the DPH injection. A similar blend of OPs was also seen in ERGs recorded from three human subjects on DPH therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yarri Y, Selzer ME, Pincus JH. Phenytoin: mechanisms of its anticonvulsant action. Ann Neurol 1986; 20: 171–84.

    Google Scholar 

  2. Rall TN, Schleifer LS. Drugs effective in the therapy of the epilepsies. In: Gilman AG, Goodman LS, Rall TW, Murad F, eds. Goodman and Gilman's The pharmacological basis of therapeutics. New York: Macmillan Publishing Company, 1985: 446–72.

    Google Scholar 

  3. White HS, Chen CF, Kemp JW, Woodbury DM. Effects of acute and chronic phenytoin on the electrolyte content and the activities of Na+, K+-, Ca2+, Mg2+- and HCO -3 -ATPases and carbonic anhydrase of neonatal and adult rat cerebral cortex. Epilepsia 1985; 26: 43–57.

    Google Scholar 

  4. White HS, Yen-Chow YC, Chow SY, Kemp JW, Woodbury DM. Effects of phenytoin on primary glial cell cultures. Epilepsia 1985; 26: 58–68.

    Google Scholar 

  5. Honda Y, Podos SM, Becker B. The effect of diphenylhydantoin on the electroretinogram in rabbits: I. Effect of concentration. Invest Ophthalmol 1973; 12: 567–72.

    Google Scholar 

  6. Honda Y, Podos SM, Becker B. The effect of diphenylhydantoin on the electroretinogram on the rabbit: II. Effects of hypoxia and potassium. Invest Ophthalmol 1973; 12: 573–8.

    Google Scholar 

  7. Mameli O, Tolu E, Melia F, Caria MA, Sechi GP, De Riu PL. Postrotatory nystagmus during phenytoin treatment. Epilepsia 1986; 27: 385–90.

    Google Scholar 

  8. Auerbach E, Burian HM. Studies on the photopic-scotopic relationships in the human electroretinogram. Am J Ophthalmol 1955; 40: 42–59.

    Google Scholar 

  9. Bornschein H, Goodman G. Studies on the a-wave in the human electroretinogram. Arch Ophthalmol 1957; 58: 431–7.

    Google Scholar 

  10. Brunette JR. Double a-waves and their relationships to oscillatory potentials. Invest Ophthalmol 1972; 11: 199–210.

    Google Scholar 

  11. Heckenlively JR, Martin DA, Rosenbaum AL. Loss of electroretinographic oscillatory potentials, optic atrophy, and dysplasia in congenital stationary night blindness. Am J Ophthalmol 1983; 96: 526–34.

    Google Scholar 

  12. Lachapelle P, Little JM, Polomeno RC. The photopic electroretinogram in congenital stationary night blindness with myopia. Invest Ophthalmol Vis Sci 1983; 24: 442–50.

    Google Scholar 

  13. Lachapelle P, Molotchnikoff S. Components of the electroretinogram: a reappraisal. Doc Ophthalmol 1986; 63: 337–48.

    Google Scholar 

  14. Lachapelle P, Molotchnikoff S. A composite nature for the photopic b-wave of the human electroretinogram as evidenced by the use of the 60 Hz notch filter. Can J Ophthalmol 1986; 21: 19–22.

    Google Scholar 

  15. Lachapelle P. Analysis of the photopic electroretinogram recorded before and after dark-adaptation. Can J Ophthalmol 1987; 22: 354–61.

    Google Scholar 

  16. Yaari Y, Selzer ME, David G. Frequency-dependent effects of phenytoin on frog functional transmission: presynaptic mechanisms. Brain Res 1985; 345: 102–10.

    Google Scholar 

  17. Gur M, Zeevi Y. Frequency domain analysis of the human electroretinogram. J Opt Soc Am 1980; 70: 53–9.

    Google Scholar 

  18. Englander RN, Johnson RN, Brickley JJ, Hanna GR. Effects of antiepileptic drugs on thalamocortical excitability. Neurology 1977; 27: 1134–9.

    Google Scholar 

  19. Bresnick GH, Korth K, Groo A, Palta M. Electroretinographic oscillatory potentials predict progression of diabetic retinopathy. Arch Ophthalmol 1984; 102: 1307–11.

    Google Scholar 

  20. Bresnick GH, Palta M. Temporal aspects of the electroretinogram in diabetic retinopathy. Arch Ophthalmol 1987; 105: 660–4.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, McGill University, Montreal, Quebec, Canada

    Pierre Lachapelle, Michael G. Quigley & Robert C. Polomeno

  2. Département de Sciences Biologiques, Université de Montréal, Montréal, Québec, Canada

    Lucie Blain & Stéphane Molotchnikoff

Authors
  1. Pierre Lachapelle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lucie Blain
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael G. Quigley
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert C. Polomeno
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stéphane Molotchnikoff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lachapelle, P., Blain, L., Quigley, M.G. et al. The effect of diphenylhydantoin on the electroretinogram. Doc Ophthalmol 73, 359–368 (1989). https://doi.org/10.1007/BF00154491

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00154491

Key words

Search

Navigation