Skip to main content
Log in

Isolation and some properties of ciguatoxin

  • Published:
Journal of Applied Phycology Aims and scope Submit manuscript

Abstract

Ciguatoxin, the principal toxin of ciguatera produced by a toxic dinoflagellate and accumulated through the food chain in the viscera of moray eels, was purified. The probable molecular formula C60H86O19 was obtained for the first time by high resolution mass spectrometry. 1H NMR spectra suggested the presence of a primary hydroxyl group suitable for preparing an antigen necessary to develop an enzyme immunoassay.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Adachi R, Fukuyo Y (1978) The thecal structure of a marine toxic dinoflagellate Gambierdiscus toxicus gen. et sp. nov. collected in a ciguatera-endemic area. Nippon Suisan Gakkaishi 45: 67–71.

    Google Scholar 

  • Bagnis R, Chanteau S, Yasumoto T (1977) Un agent étiologique vraisemblable de la ciguatera. C. R. Acad. Sc. Paris, t. 285 (4 juillet 1977). Serie D: 105–107.

  • Bagnis R, Kuberski T, Laugier R (1979) Clinical observations on 3,009 cases of ciguatera (fish poisoning) in the South Pacific. Am. J. Trop. Med. Hyg. 28: 1067–1073.

    PubMed  CAS  Google Scholar 

  • Boyarsky LL, Rayner ME (1970) The effect of ciguatera toxin on Aplysia neurons. Proc. Soc. exp. biol. Med. 134: 332–335.

    PubMed  CAS  Google Scholar 

  • Chungue E, Bagnis R, Fusetani N, Yasumoto T (1977) Le complexe toxinique des poissons peroquets. Biochimie 59: 739–741.

    PubMed  CAS  Google Scholar 

  • Halstead BW (1965) Poisonous and Venomous Marine Animals of the World, 1. U.S. Gov. Print. Office, Washington, D.C., 994 pp.

    Google Scholar 

  • Joh YG, Scheuer PJ (1986) The chemical nature of scaritoxin. Mar. fish. Review 48: 19–22.

    Google Scholar 

  • Meier J, Theakston RDG (1986) Approximate LD50 determination of snake venoms using eight to ten experimental animals. Toxicon 24: 395–401.

    Article  PubMed  CAS  Google Scholar 

  • Nukina M, Koyanagi LM, Scheuer PJ (1984) Two interchangeable forms of ciguatoxin. Toxicon 22: 169–176.

    Article  PubMed  CAS  Google Scholar 

  • Quod JP, Legrand AM (1987) Effects of partially purified ciguatoxin from moray eel Gymnothorax javanicus on action potential of isolated rat heart. In Gopalakrishnakone P, Tan CK (eds), Progress in Venom and Toxin Research. Faculty of Med., National University of Singapore, Singapore, 394–404.

    Google Scholar 

  • Scheuer PJ, Takahashi W, Tsutsumi J, Yoshida T (1967) Ciguatoxin: isolation and chemical nature. Science 155: 1267–1268.

    PubMed  CAS  Google Scholar 

  • Seino A, Kobayashi M, Momose K, Yasumoto T, Ohizumi Y (1988) The mode of inotropic action of ciguatoxin on guinea-pig cardiac muscle. Br. J. Pharmacol. 95: 876–882.

    PubMed  CAS  Google Scholar 

  • Tachibana K (1980) Structural studies on marine toxins. Ph.D. Thesis, University of Hawaii, Honolulu.

  • Tachibana K, Nukina M, Joh YG, Scheuer PJ (1987) Recent developments in the molecular structure of ciguatoxin. Biol. Bull. 172: 122–127.

    CAS  Google Scholar 

  • Yasumoto T, Scheuer PJ (1969) Marine toxins of the Pacific VIII ciguatoxin from moray eel livers. Toxicon 7: 273–276.

    Article  PubMed  CAS  Google Scholar 

  • Yasumoto T, Hashimoto, Bagnis R, Randall JE, Banner AH (1971) Toxicities of the surgeonfishes. Nippon Suisan Gakkaishi 31: 724–734.

    Google Scholar 

  • Yasumoto T, Nakajima I, Bagnis R, Adachi R (1977) Finding of a dinoflagellate as a likely culprit of ciguatera. Nippon Suisan Gakkaishi 43: 1021–1026.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

author for correspondence

Rights and permissions

Reprints and permissions

About this article

Cite this article

Legrand, A.M., Litaudon, M., Genthon, J.N. et al. Isolation and some properties of ciguatoxin. J Appl Phycol 1, 183–188 (1989). https://doi.org/10.1007/BF00003882

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00003882

Key words

Navigation