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Impact of religiosity/spirituality on biological and preclinical markers related to cardiovascular disease. Results from the SPILI III study

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Abstract

OBJECTIVE

This study aimed at exploring to what extent psychosocial factors, such as religiosity/spirituality and sense of coherence, mediate the negative effects of stress on a variety of cardiometabolic indicators, i.e., hypertension, diabetes, cardiovascular and cerebrovascular disease, and atherosclerotic bio-clinical markers.

DESIGN

A total of 220 subjects (66.2±16.0 years) of the SPILI III cohort (1988–2012) attending a primary care setting in Spili, a rural town in crete, represented the target group for the present study. Of these, 195 (88.6%) participated in the re-examination (67.2±15.2 years). All participants underwent a standardized procedure including evaluation of anthropometric measurements, biochemical indicators of atherosclerosis, stress hormones, in parallel with ultrasound measurements of carotid intima media thickness (IMT). Religiosity, spirituality and sense of coherence were evaluated with the use of international questionnaires translated into the Greek language and linguistically validated.

RESULTS

Participants with higher levels of religious and spiritual beliefs presented lower levels of carotid IMT (1.01±0.101 vs 1.53±0.502 mm, p<0.001). Patterns of inverse relationships were also observed between religiosity/spirituality and prevalence of diabetes (35.1% vs. 2%, p<0.001) with an estimated diabetes risk, fully adjusted odds ratio, 95% CI: 0.91 (0.87–0.94). Highly religious participants presented lower serum cortisol levels (12.3±5.8 vs. 18.2±5.1 µg/dl, p<0.001). Sense of coherence was positively associated with religiosity/spirituality [mean SOC (SD): 123±20 vs. 158±15) p<0.001].

CONCLUSIONS

These findings may be associated with a possible favourable effect of religiosity/spirituality on several cardio-metabolic determinants, therefore deserving further attention by healthcare practitioners and researchers.

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Author information

Authors and Affiliations

  1. Clinic of Social and Family Medicine, School of Medicine, University of Crete, P.O. Box 2208, Heraklion, Greece

    Dimitrios Anyfantakis, Emmanouil K. Symvoulakis, Sue Shea & Christos Lionis MD, PhD, FRCGP(Hon) (Professor of General Practice and Primary Care)

  2. Department of Nutrition and Dietetics, Harokopio University, Athens, Greece

    Demosthenes B. Panagiotakos

  3. Department of Radiology, School of Medicine, University of Crete, Heraklion, Greece

    Dimitrios Tsetis

  4. Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklion, Greece

    Elias Castanas

  5. Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece

    Maria Venihaki

Authors
  1. Dimitrios Anyfantakis
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  2. Emmanouil K. Symvoulakis
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  3. Demosthenes B. Panagiotakos
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  4. Dimitrios Tsetis
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  5. Elias Castanas
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  6. Sue Shea
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  7. Maria Venihaki
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  8. Christos Lionis MD, PhD, FRCGP(Hon)
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Correspondence to Christos Lionis MD, PhD, FRCGP(Hon).

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Anyfantakis, D., Symvoulakis, E.K., Panagiotakos, D.B. et al. Impact of religiosity/spirituality on biological and preclinical markers related to cardiovascular disease. Results from the SPILI III study. Hormones 12, 386–396 (2013). https://doi.org/10.1007/BF03401304

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