References
Eisenbarth G.S. Type I diabetes mellitus: a chronic autoimmune disease. N. Engl. J. Med. 314: 1360, 1986.
Bottazzo G.F., Florin-Christensen A., Doniach D. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 2: 1279, 1974.
Palmer J., Asplin C.M., Clemons P., Lyen K., Tatputi O., Raghu P.K., Pasguette T.L. Insulin antibodies in insulin-dependent diabetes before insulin treatment. Science. 222: 1337, 1983.
Solimena M., Folli F., Aparisi R., Pozza G., De Camilli P. Autoantibodies to GABAergic neurons and pancreatic ß-cells in Stiff-Man syndrome. N. Engl. J. Med. 322: 1555, 1990.
Bækkeskov S., Aanstoot H.J., Christgau S., Reetz A., Solimena M., Cascalho M., Folli F., Richter-Olesen H., De Camilli P. Identification of the 64 Kd autoantigen in insulin-dependent diabetes mellitus as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 347: 151, 1990.
Bækkeskov S., Nielsen J., Nielsen J.H., Marner B.T., Bilde J., Ludvigsson, Lernmark A. Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298: 167, 1982.
Castano L., Russo E., Zhou L., Lipes M.A., Eisenbarth G. Identification and cloning of a granule autoantigen (Carboxypeptidase-H) associated with type I diabetes. J. Clin. Endocrinol. Metab. 73: 1197, 1991.
Karjalainen J., Martin J., Knip M., Ilonen J., Robinson B.H., Avilahti E., Akerblom H.K., Dosch H.M. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N. Engl. J. Med. 327: 302, 1992.
Pietropaolo M., Castano L., Babu S., Buelow R., Kuo Y-L.S., Martin S., Martin A., Powers A.C., Prochazka M., Naggert J., Leiter J.H., Eisenbarth G.S. Islet cell autoantigen 69kDa (ICA69): molecular cloning and characterization of a novel diabetes associated autoantigen. J. Clin. Invest. 92: 359, 1993.
Nayak R.C., Omar M.A.K., Rabizadeh A., Srikanta S., Eisenbarth G.S. “Cytoplasmic” islet cell antibodies: evidence that the target antigen is a sialogycogonjugate. Diabetes. 34: 617, 1985.
Dotta F., Ziegler R., O’Neill J., Nayak R., Eisenbarth G.S., Appel M. Islet autoimmunity identification and initial characterization of metabolically regulatable pancreatic gangliosides. Diabetologia. 19: 483a (Abstract), 1989.
Elias D., Markovits D., Reshef T., van der Zee R., Cohen I.R. Induction and therapy of autoimmune diabetes in the non-obese diabetic mouse by a 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA. 87: 1567, 1990.
Elias D., Reshef T., Birk O., van der Zee R., Walker M.D., Cohen I.R. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA. 88: 3088, 1991.
Kampe O., Velloso L., Andersson A., Karlsson A. No role for 65-kDa heat-shock protein in diabetes. Lancet. 336: 1250, 1990.
Atkinson M.A., Holmes L.A. Sharp D.W., Lacy P.E., Maclaren N.K. No evidence for serological autoimmunity toward islet cell heat shock protein in insulin-dependent diabetes. J. Clin. Invest. 7: 721, 1991.
Roep B.O., Ardent S.D., de Vries R.R.P., Hutton J.C. T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature. 345: 632, 1990.
Roep B.O., Kallan A.A., Hazenbos W.L.W., Bruining G.J., Baileys E.M. Ardern S.D., Hutton J.C., de Vries R.R.P. T cell reactivity to 38kD insulin-secretory-granule protein in patients with recent-onset type I diabetes Lancet. 337: 1439, 1991.
Sutherland D.E., Sibley R., Xu X.Z., Michael A., Srikanta A.M., Taub F., Najarian J., Goetz F.C. Twin to twin pancreas transplatation: reversal and reenactment of the pathogenesis of type I diabetes Trans. Assc. Am. Phys. 97: 80, 1984.
Miller B.J., Apple M.C., O’Neil J.J., Wicker L.S. Both the Lyt-2+ and L3T4+ T-cell subsets are required for the transfer of diabetes in non-obese diabetic mice. J. Immunol. 140: 52, 1988.
Hayward A.R., Cobbold S.P., Waldman H., Cooke A., Simpson E. Delay in onset of insulitis in NOD mice following a single injection of CD4 and CD8 antibodies. J. Autoimmun. 1: 91, 1988.
Reich E.P., Sherwin R.S., Kanagawa O., Janeway C.A.J. An explanation for the protective effect of MHC class II I-E molecule in murine diabetes. Nature. 341: 326, 1989.
Kaufman D.L., Clare-Salzer M., Tian J., Forsthuber T., Ting G.S.P., Robinson P., Atkinson M.A., Sercarz E.E., Tobin A.J., Lehmann P.V. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature. 366: 69, 1993.
Tisch R., Yang X.-D., Singer S.M., Liblau R.S., Fugger L., McDevitt H.O. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature. 366: 72, 1993.
Roberts E., Frankel S. Further studies of glutamic acid decarboxylase in brain. J. Biol.Chem. 188: 789, 1951.
Erlander M.G., Tobin A.J. The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem. Res. 16: 215, 1991.
Karlsen A.E., Hagopian W.A., Grubin C.E., Dube S., Disteche C.M., Adler D.A., Barmeier H., Mathewes S., Grant F.J., Foster D., Lernmark A. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc. Natl. Acad. Sci. USA. 88: 8337, 1991.
Bu D.-F., Erlander M.G., Hitz B.C., Tillakaratne N.J.K., Kaufman D.L., Wagner-McPherson C.B., Evans G.A., Tobin A.J. Two human glutamate decarboxylases 65-kDa GAD and 67-kDa GAD are each encoded by a single gene. Proc. Natl. Acad. Sci. USA. 89: 2115, 1992.
Wyborski R.J., Bond R.W., Gottlieb D.I. Characterization of a cDNA coding for rat glutamic acid decarboxylase. Molecular Brain Research. 8: 193, 1990.
Julien J.F., Samama P., Mallet J. Rat brain glutamic acid decarboxylase sequence deduced from a cloned cDNA. J. Neurochem. 54: 703, 1990.
Erlander M.G., Tillakaratne N.J.K., Feldblum S., Patel N., Tobin A.J. Two genes encode distinct glutamate decarboxylases. Neuron 7: 91, 1991.
Michelsen B.K., Petersen J.S., Boel E., Møldrup A., Dyrberg T., Madsen O.D. Cloning characterization and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA. 88: 8754, 1991.
Katarova Z., Szabo G., Mugnaini E., Greenspan R.J. Molecular identification of the 62 kd form of glutamic acid decarboxylase from the mouse. European J. Neuroscience. 2: 190, 1990.
Lee D.S., Tian J., Phan T., Kaufman D.L. Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65). Biochem. Biophys. Acta. 1216: 157, 1993.
Kobayashi Y., Kaufman D.L., Tobin A.J. Glutamic acid decarboxylase cDNA: nucleotide sequence encoding and enzymatically active fusion protein. J. Neurosci. 7: 2768, 1987.
Jackson F.R., Newby L.M., Kulkarni S.J. Drosophila GABAergic systems: sequence and expression of glutamic acid decarboxylase. J. Neurochem. 54: 1068, 1990.
Christgau S., Aanstoot H.-J., Schierbeck H., Begley K., Tullin S., Hejnaes K., Bækkeskov S. Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic ß-cells by palmitoylation in the NH2-terminal domain. J. Cell. Biol. 118: 309, 1992.
Solimena M., Aggujaro D., Muntzel C., Dirkx R., Butler M., De Camilli P., Hayday A. Association of GAD-65 but not of GAD-67 with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region. Proc. Natl. Acad. Sci. USA. 90: 3073, 1993.
Shi Y., Veit B., Bækkeskov S. Amino acid residues 24–31 but not palmitoylation of cysteins 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase GAD65. J. Cell. Biol. 124: 927, 1994.
Solimena M., Dirkx R., Radzynski M., Mundigl O., De Camilli P. A signal located within amino acids 1–27 of GAD65 is required for its targeting to the Golgi complex region. J. Cell Biol. In press, 1994.
Brilliant M.H., Szabo G., Katarova Z., Kozak C.A., Glaser T.M., Greenspan R.J., Housman D.E. Sequences homologous to glutamic acid decarboxylase cDNA are present on mouse chromosomes 2 and 10. Genomics. 6: 115, 1990.
Edelhoff S., Grubin C.E., Karlsen A.E., Alder D.A., Foster D., Disteche C.M., Lernmark A. Mapping of glutamic acid decarboxylase (GAD) genes. Genomics 17: 93, 1993.
Maras B, Sweeney G, Barra D., Bossa F, John RA. The amino acid sequence of glutamate decarboxylase from Escherichia coli. Evolutionary relationship between mammalian and bacterial enzymes: Eur. J. Biochem. 204: 93, 1992.
Baum G., Chen Y., Arazi T., Takatsuji H., Fromm H. A plant glutamate decarboxylase containing a calmodulin binding domain. Cloning sequence and functional analysis. J. Biol. Chem. 268: 19610, 1993.
Martin D.L. Regulatory properties of brain glutamate decarboxylase. Cell. Mol. Neurobiol. 7: 237, 1987.
Kaufman D.L., Houser C.R., Tobin A.J. Two forms of the GABA synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem. 56: 720, 1991.
Martin D.L., Martin S.B., Wu S.J., Espina N. Cofactor interactions and the regulation of glutamate decarboxylase activity. Neurochem. Res. 16: 243, 1991a.
Martin D.L., Martin S.B., Wu S.J., Espina N. Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain. J. Neurosci. 11: 2725, 1991b.
Mugnaini E., Oertel W.H. An atlas of the distribution of GABAergic neurons and terminals in the rat CNS as revealed by GAD immunohistochemistry. In: Handbook of Chemical Neuroanatomy Vol. 4: GABA and Neuropeptides in the CNS Part I. A. Bjorklund and T. Hökfelt, editors. Elsevier Science Publishers B.V. Amsterdam. 436, 1985.
Esclapez M., Tillakaratne N.J.K., Kaufman D.L., Tobin A.J., Houser C.R. Comparative localization of two forms of glutamic acid decarboxylase and their mRNA in rat brain support the concepts of functional differences between the forms. J. Neurosci. 14: 1834, 1994.
Vincent S.R., Hökfelt T., Wu J.-Y., Elde R.P., Morgan L.M., Kimmel J.R. Immunohistochemical studies of the GABA system in the pancreas. Neuroendocrin. 36: 197, 1983.
Okada Y. In: GABAergic Mechanisms in the Mammalian Periphery. S.L. Erdo and N.G. Bower editors. Raven Press New York. 223, 1986.
Garry D.J., Garry M.G., Sorenson R.L. Ultrastructural immunocytochemical localization of L-glutamate decarboxylase and GABA in rat pancreatic zymogen granules. Cell Tssue Res. 252: 191, 1988.
Reetz A., Solimena M., Matteoli M., Folli F., Takei K., De Camilli P. GABA and pancreatic ß-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion. EMBO J. 10: 1275, 1991.
Erdo S.L., Joo F., Wolff J.F. Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: further evidence for non-neuronal GABA system. Cell Tissue Res. 255: 431, 1990.
Tillakaratne N.J.K., Erlander M.G., Collard M.W., Greif K.F., Tobin A.J. Glutamate decarboxylases in nonneuronal cells of rat testis and oviduct: differential expression of GAD65 and GAD67. J. Neurochem. 58: 618, 1992.
Persson H., Pelto-Huikko M., Metsis M., Soder O., Brene S., Skog S., Hökfelt T., Ritzen E.M. Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells Mol. Cell. Biol. 10: 4701, 1990.
Faulkner-Jones B.E., Cram D.S., Kun J., Harrison L.C. Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic ß-cells and other peripheral tissues of mouse and rat. Endocrinol. 133: 2962, 1993.
Petersen J.S., Russel S., Marshall M.O., Kofod H., Buschard K., Cambon N., Karlsen A.E., Boel E., Hagopian W.A., Hejnaes K.R., Moody A., Dyrberg T., Lernmark Å., Madsen O.D., Michelsen B.K. Differential expression of glutamic acid decarboxylase in rat and human islets. Diabetes. 42: 484, 1993.
Velloso L.A., Kampe O., Eizirik D.L., Hallberg A., Andersson A., Karlsson F.A. Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets. Diabetologia. 36: 39, 1993a.
Kim J., Richter W., Aanstoot H.-J., Shi Y., Fu Q., Rajotte R., Warnock G., Bækkeskov S. Differential expression of GAD65 and GAD67 in human rat and mouse pancreatic islets. Diabetes. 42: 1799, 1993.
Chang Y.-C., Gottlieb D.I. Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase. J. Neurosci. 8: 2123, 1988.
De Camilli P., Jahn R. Pathways to regulated exocytosis in neurons. Ann. Rev. Physiol. 52: 625, 1990.
Maycox P.R., Hell J.W., Jahn R. Amino acid neurotransmission: spotlight on synaptic vesicles. Trends Neurosci. 13: 83, 1990.
Sorenson R.L., Garry D.G., Brelje T.C. Structural and functional considerations of GABA in islets of Langerhans ß-cells and nerves. Diabetes. 41: 1365, 1991.
Ahner-Hilger G., Widenmann B. The amphicrine pancreatic cell line AR42J secretes GABA and amylase by seperate regulated pathways. FEBS Lett. 314: 41, 1992.
Thomas-Reetz A., Hell J.W., During M.J., Walch-Solimena C., Jahn R., De Camilli P. A γ-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic ß cells. Proc. Natl. Acad. Sci. USA 90: 5317, 1993.
Thomas-Reetz A., De Camilli P. A role for synaptic vesicles in non-neuronal cells: clues from pancreatic ß-cells and from chromaffin cells. Faseb. J. 8: 209, 1994.
Christgau S, Schierbeck H, Aanstoot H-J, Aagard L., Begley K, Kofod H, Hejnes K, Bækkeskov S. Pancreatic ß-cells express two autoantigenic forms of glutamic acid decarboxylase a 65kDa hydrophilic form and a 64kDa amphiphilic form which can be both membrane-bound and soluble. J. Biol. Chem. 266: 21254, 1991.
Solimena M., Folli F., Denis-Donini S., Comi G.C., Pozza G., De Camilli P., Vicari A.M. Autoantibodies to glutamic acid decarboxylase in a patient with Stiff-Man syndrome epilepsy and type I diabetes mellitus. N. Engl. J. Med. 318: 1012, 1988.
Moersch F.P., Woltman H.W. Progressive and fluctuating muscular rigidity and spasm (stiff-man syndrome): report of a case and some observation in 13 other cases. Mayo Clin. Proc. 31: 421, 1956.
Blum P., Jankovic J. Stiff-Person syndrome: an autoimmune disease. Movement Dis. 6: 12, 1991.
McEvoy K.M. Stiff-Man syndrome. Mayo Clinic. Proc. 66: 300, 1991.
Meinck H.M., Ricker K., Hulser P.J., Schmid E., Pfeiffer J., Solimena M. Stiff-Man syndrome: clinical and laboratory findings in eight patients. J. Neurol. 241: 157, 1994.
Meinck H.M., Ricker K., Conrad B. The Stiff-Man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and ther response to clorimipramine clonidine and tizanidine. J. Neurol. Neurosurg. Psychiatry 47: 280, 1984.
Lorish T.R., Thorsteinsson G., Howard Jr., F.M. Stiff-man syndrome updated. Mayo Clin. Proc. 64: 629–636, 1989.
Solimena M., De Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus. TINS. 14: 452, 1991.
Gorin F., Baldwin B., Tait R., Pathak R., Seyal M., Mugnaini E. Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity. Ann Neurol. 28: 71, 1990.
Young W. The Stiff-man syndrome. Br. J. Clic. Pract. 20: 507, 1966.
Martinelli P., Montagna P. Exteroceptive reflexes abnormalities in stiff-man syndrome. J. Neurol. Neurosurg. Psychiatry 48: 92, 1985.
Meldrum B.S. Anatomy physiology and pathology of epilepsy. Lancet 336: 231, 1990.
Butler M., Solimena M., Dirkx R., Hayday A., De Camilli P. Identification of a dominant epitope of glutamic acid decarboxylase (GAD65) recognized by autoanti-bodies in Stiff-Man syndrome. J. Exp. Med. 178: 2097, 1993.
Vicari A., Folli F., Pozza G., Comi G.C., Comola M., Canal N., Besana C., Borri A., Tresoldi M., Solimena M., De Camilli P. Plasmapheresis in the treatment of Stiff-Man syndrome. New Engl. J. Med. 320: 1499, 1989.
Harding A.E., Thompson P.D., Kocen R.S., Batchelor J.R., Davey N., Marsden C.D. Plasma exchange and immunosuppression in Stiffman syndrome. Lancet 2: 915, 1989.
Brashear H.R., Phillips L.H. Autoantibodies to GABA-ergic neurons and response to plasmapheresis in stiff-man syndrome. Neurology 41: 1588, 1992.
George T.M., Burke J.M., Sobotka P.A., Greenberg H.S., Vinik I. Resolution of Stiff-man syndrome with cortisol replacement in a patient with deficiences of ACTH growth hormone and prolactin. N. Engl. J. Med. 310: 1511, 1984.
Piccolo G., Cosi V. Stiff-man syndrome dysimmune disorder and cancer. Ann. Neurol. 26: 205, 1989.
McEvoy K.M., Ahslskog J.E. Antibody-positive stiff-man syndrome responding to immunosuppression. Neurology 41: 143, 1991.
Gianani R., Pugliese A., Bonner-Weir S., Shiffrin A.J., Soeldner J.S., Erlich H., Awdeh Z., Alper C.A., Jackson R.A., Eisenbarth G.S. Prognostically significant heterogeneity of cytoplasmic islet cell autoantibodies in relatives of patients with type I diabetes. Diabetes. 41: 347, 1992.
Atkinson M.A., Kaufman D.L., Campbell L., Tobin A.J., Maclaren N.K. Islet cells cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. J. Clin. Invest. 91: 350, 1993.
Gianani R., Pugliese A., Verge C., Moromisato R., Yamada K., Butler M., Solimena M., De Camilli P., Erlich H., Jackson R., Eisenbarth G.S. Characterization of three subsets of ICA: restricted (mouse negative human and rat positive GAD absorbable); non-restricted (human mouse rat positive and not GAD absorbable) and human specific (human specific not GAD absorbable). Diabetes (submitted).
Williams A.C., Nutt J.G., Hare T. Autoimmunity in Stiff-man syndrome. Lancet 2: 222, 1988.
Pugliese A., Solimena M., Awdeh Z.L., Alper C.A., Bugawan T., Erlich H.A., De Camilli P., Eisenbarth G.S. Association of HLA-DQB1*0201 with Stiff-Man syndrome. J. Clin. Endocrinol. Metab. 1550, 1993.
Baisch J.M., Weeks T., Giles R., Hoover M., Stastny P., Capra J.D. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N. Engl. J. Med. 322: 1836, 1990.
Caillat-Zucman S., Garchon H.J., Timsit J., Assan R., Boitard C., Djilali-Saiah I., Bougneres P., Bach J.F. Age dependent HLA genetic heterogeneity of type I insulin-dependent diabetes mellitus. J. Clin. Invest. 90: 2242, 1992.
Bækkeskov S., Landin M., Kristensen J., Srikanta S., Bruining G., Mandrup-Poulsen T., de Beaufort C., Soeldner J., Eisenbarth G.S., Lindgren F., Sundquist G., Lernmark Å. Antibodies to a 64000 M human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J. Clin. Invest. 79: 926, 1987.
Atkinson M.A., Maclaren N.K., Scharp D.W., Lacey P.E., Riley W.J. 64000 Mr autoantibodies as predictors of insulin-dependent diabetes mellitus. Lancet. 335: 1357, 1990.
Hagopian W.A., Karlson A.E., Gottsater A., Landin-Olsson M., Grubin C.E., Sundkvist G., Petersen J.S., Boel E., Cyrberg T., Lernmark Å. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type. J. Clin. Invest. 91: 368, 1993.
Rowley M.J., MacKay R., Chen Q., Knowles W.J., Zimmet P.Z. Autoantibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus. Diabetes 41: 548, 1992.
Bækkeskov S., Dyrberg T., Lernmark Å. Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science. 224: 1348, 1984.
Karlsen A.E., Hagopian WA, Petersen J.S., Boel E., Dyrberg T., Grubin C.E., Michelsen B.K., Madsen O.D., Lernmark Å. Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64000-M(r) autoantibodies. Diabetes. 41: 1355, 1992.
Richter W., Eiermann T.H., Endl J., Seissler J., Wolfhart S., Brandt M., Jungfer H., Scherbaum W.A. Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies. Diabetologia 36: 785–790, 1992.
Richter W., Shi Y., Bækkeskov S. Autoreactive epitopes defined by diabetes-association human monoclonal antibodies are localizaed in the middle and C-terminal domains of the smaller form of glutamate decarboxylase. Proc. Natl. Acad. Sci. USA 90: 2832, 1993.
Velloso L.A., Kampe O., Hallberg A., Christmanson L., Betsholtz C., Karlsson F.A. Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. J. Clin. Invest. 91: 2084, 1993.
Kaufman D.L., Erlander M.G., Claire-Salzler M., Atkinson MA, Maclaren N.K., Tobin A.J. Autoimmunity to two forms of glutamate decarboxylase in insulin dependent diabetes mellitus. J. Clin. Invest. 89: 283, 1992.
Mauch L., Seissler J., Haubruck H., Cook N.J., Abney C.C., Berthold H., Wirbelauer C., Liedvogel B., Scherbaum W.A., Northemann W. Baculovirus-mediated expression of human 65 kDa and 67 kDa glutamic acid decarboxylases in SF9 insect cells and their relevance in diagnosis of insulin-dependent diabetes mellitus. J. Biochem. 113: 699, 1993.
DeAizpurua H.J., Harrison L.C., Cram D.S. An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM. Diabetes 41: 1182, 1992.
Martino G.V., Tappaz M.L., Braghi S., Dozio N., Canal N., Pozza G., Bottazzo G.F., Grimaldi L.M., Bosi E. Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: relation to insulin-dependent diabetes mellitus and islet cell antibodies. J. Autoimm. 4: 915, 1991.
Christie M.R., Brown T.J., Cassidy D. Binding of antibodies in sera from type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme. Diabetologia 35: 380, 1992.
Groop L., Miettinen A., Groop P.H., Meri S., Koskimies S., Bottazzo G.F. Organ-specific autoimmunity and HLA-DR antigens as markers for beta-cell destruction in patients with type II diabetes. Diabetes 37: 99, 1988.
Di Mario U., Irvine W.J., Borsey D.Q., Kyner J.L., Weston J., Galfo C. Immune abnormalities in diabetic patients not requiring insulin at diagnosis. Diabetologia 25: 392, 1983.
Tuomi T., Groop L.C., Zimmet P.Z., Rowley M.J., Knowles W., Mackay I.R. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42: 359, 1993.
Atkinson M.A., Kaufman D.L., Campbell L., Gibbs K.A., Shah S.C., Bu D.F., Erlander M.G., Tobin A.J., Maclaren N.K. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339: 458, 1992.
Harrison L.C., Honeyman M.C., DeAizpurua H.J., Schmidli R.S., Colman P.G., Tait B.D., Cram D.S. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 341: 1365, 1993.
Mitsumoto H., Schwartzman M.J., Estes M.L., Chou S.M., La Franchise E.F., De Camilli P., Solimena M. Sudden death and paroxysmal autonomie dysfunction in Stiff-man syndrome. J. Neurol. 238: 91, 1991.
Pujol-Borrell R., Todd I., Doshi M., Gray D., Feldmann M., Bottazzo G.F. Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. Clin. Exp. Immunol. 65: 128.
Wong G.H., Bartlett P.F., Clark-Lewis I., Battye F., Schrader J.W. Inducible expression of H-2 and la antigens on brain cells. Nature 310: 688, 1984.
Joly E., Oldstone M.B. Neuronal cells are deficient in loading peptides onto MHC class I molecules. Neuron 8: 1185, 1992.
Fohlman J., Friman G. Is juvenile diabetes a viral disease? Annals of Medicine 25: 569, 1993.
Solimena M., De Camilli P. Diabetes: spotlight on a neuronal enzyme. Nature. 366: 15, 1993.
Greif K.F., Erlander M.G., Tillakaratne N.J.K., Tobin A.J. Postnatal expression of glutamate decarboxylases in developing rat cerebellum. Neurochem. Res. 16: 235, 1991.
Mamula M.J., Lin R.H., Janeway Jr C.A., Hardin J.A. Breaking T cell tolerance with foreign and self coimmunogens. A study of autoimmune B and T cell epitopes of cytochrome c. Journal of Immunology 149: 789, 1992.
Hafler D.A., Matsui M., Wucherpfennig K.W., Ota K., Weiner H.L. The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis Ann. N. Y. Acad. Sci. 636: 251, 1991.
Critchfield J.M., Racke M.K., Zuniga-Pflucker J.C., Cannella B., Raine C.S., Goverman J., Lenardo M.J. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 25: 1139, 1994.
Weiner H.L., Mackin G.A., Matsui M., Orav E.J., Khoury S.J., Dawson D.M., Hafler D.A. Double blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science 259: 1321, 1993.
Tisch R., McDevitt H.O. Antigen-specific immunotherapy: is it a real possibility to combat T-cell-mediated autoimmunity? Proc. Nat. Acad. Sci. USA 91: 437, 1994.
Gelber C., Paborsky L., Singer S., McAteer D., Tisch R., Jolicoeur C., Buelow R., McDevitt H.O., Fathman C.G. Isolation of nonobese diabetic mice T-cells that recognize novel autoantigens involved in the early events of diabetes. Diabetes 43: 33, 1994.
Craft J., Mamula M., Ohosone Y., Boire G., Gold H., Hardin J. snRNPs and scRNPs as autoantigens: clues to the etiology of the connective tissue diseases. Clin. Rheumat. 9: 10, 1990.
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Solimena, M., Butler, M.H. & De Camilli, P. GAD, diabetes, and Stiff-Man syndrome: Some progress and more questions. J Endocrinol Invest 17, 509–520 (1994). https://doi.org/10.1007/BF03347745
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DOI: https://doi.org/10.1007/BF03347745