Summary
Placental transfer and excretion into milk of [125I]-rhIL-11 (recombinant human interleukin-11) after subcutaneous administration in female rats were investigated. After administration of [125I]-rhIL-11 to rats on the 14th day of gestation, radioactivity in the kidney was the highest among excised tissues, being 3 times higher than that in the plasma at 1.5 h. Radioactivity in other tissues, including the mammary gland, ovary, uterus, placenta and amniotic fluid, was lower than that in the plasma. Although radioactivity in fetuses was detected 6 h after administration, the level was only 2% of the plasma concentration in dams, and the radioactivity was not found in fetal-derived TCA precipitates. These results indicate that rhIL-11 does not readily pass through the placenta into the fetus. After subcutaneous administration of [125I]-rhIL-11 to lactating rats 14 days after delivery, radioactivity in milk was 1.1–1.6 times that in the plasma of dams. Radioactivity in clotted milk in the stomachs of suckling infants was almost equal to that in the dam’s milk; however, only a small amount of radioactivity was detected in infant kidneys.
Similar content being viewed by others
References
Yonemura Y., Kawakita M., Masuda T., Fujimoto K., Takatsuki K. (1993): Effect of recombinant human interleukin-11 on rat megakaryopoiesis and thrombopoiesis in vivo: comparative study with interleukin-6. Br. J. Haematol., 84, 16–23.
Neben T.Y., Loebelenz J., Hayes L. et al. (1993): Recombinant human interleukin-11 stimulates megakaryocytopoietisis and increases peripheral platelets in normal and splenectomized mice. Blood, 81, 901–908.
Hangog G., Yin T., Cooper S., Schendel P., Yang Y.C., Broxmeyer H.E. (1993): In vivo effects of recombinant interleukin-11 on myelopoiesis in mice. Blood, 81, 965–972.
Yin T., Miyazawa K., Yang Y. (1992): Characterization of interleukin-11 receptor and protein tyrosine phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells. J. Biol. Chem., 267, 8347–8351.
Misaizu T., Shinkai H., Hirosawa T., Kikuchi K., Tokiwa T. (1990): Metabolic fate of KRN8601: transfer of125I-KRN8601 into fetus and milk in pregnant or lactating rats. Xenobio. Drug Metab. Dispos., 5, 307–314.
Niwa T., Suzuki M., Takano N., Fujimura Y. (1994): Studies on metabolic fate of avicatonin(II) — feto-placental transfer and excretion into milk in rats. Jpn. Pharmacol. Ther., 22, S3315-S3323.
Oikawa K., Kamimura H., Watanabe T. et al. (1996): Metabolic fate of YM866, a novel fibrinolytic agent (II) feto-placental transfer and excretion into milk in rats. Xenobiot. Drug Metab. Dispos., 11, 30–37.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Uchida, T., Aoyama, K., Mori, K. et al. Pharmacokinetics of [125I]-recombinant human interleukin-11:. Eur. J. Drug Metab. Pharmacokinet. 23, 411–416 (1998). https://doi.org/10.1007/BF03192302
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03192302