Skip to main content
SpringerLink
Log in

Study on the absorption of vinpocetine and apovincaminic acid

  • Published:
European Journal of Drug Metabolism and Pharmacokinetics Aims and scope Submit manuscript

Summary

The absorption of vinpocetine (Cavinton) and apovincaminic acid, compounds showing a marked difference in their physico-chemical properties, was studied in rats inin situ loop experiments by using radiolabelled compounds. In the case of apovincaminic acid, the investigations also involved the estimation of the portion of radioactivity excreted in urine and faeces after i.v. and p.o. administration of the compound. According to our results, it can be concluded that both vinpocetine and apovincaminic acid are absorbed from the gastrointestinal tract — apovincaminic acid mainly from the stomach, while vinpocetine is absorbed from the small intestine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vereczkey L. (1985): Pharmacokinetics and metabolism of vincamine and related compounds. Eur. J. Drug Metab. Pharmacokinet., 10, 89–103.

    Article  PubMed  CAS  Google Scholar 

  2. Kozma M., Pudleiner P., Vereczkey L. (1982): Deterrmination of apovincaminic acid in biological samples by high-performance liquid chromatography. J. Chromatogr., 241, 177–182.

    Article  PubMed  CAS  Google Scholar 

  3. Polgar M., Vereczkey, L. (1982): Determination of apovincaminic acid in human plasma by gas-liquid chromatography. J. Chromatogr., 241, 29–32.

    Article  PubMed  CAS  Google Scholar 

  4. Houston J.B., Upschall D.G., Bridges J.W. (1974): A re-evaluation of the importance of partition coefficients in the gastrointestinal absorption of nutrients. J. Pharmacol. Exp. Ther., 189, 245–254.

    Google Scholar 

  5. Mahin D.T., Lofberg R.T. (1970): Determination of several isotopes in tissue by wet oxidation. In: Bransome E.D. (ed.) Current Status of Liquid Scintillation Counting. New York, Grune and Stratton Inc., 212–221.

    Google Scholar 

  6. Ritschel W.A. (1986): Handbook of Basic Pharmacokinetics Drug Intelligence Publications, inc. Hamilton, 1–43.

  7. Uemara I., Uda F., Ohashi H., et al. (1982): The metabolic fate of TVC-3B in rats. Jpn. Pharmacol. Ther., 10, 1907–1929.

    Google Scholar 

  8. Polgár M., Vereczkey L., Nyári I. (1985): Pharmacokinetics of vinpocetine and its metabolite apovincaminic acid in plasma and cerebrospinal fluid after intravenous infusion. Effect of drug on the cerebral blood flow. J. Pharm. Biomed. Anal., 3, 131–139.

    Article  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. L. Vereczkey

    Present address: Biorex R&D, PO Box 67, 1540, Budapest, Hungary

Authors and Affiliations

  1. Chemical Works of Gedeon Richter Ltd, 1475, PO Box 27, Budapest 10, Hungary

    P. Pudleiner & L. Vereczkey

Authors
  1. P. Pudleiner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Vereczkey
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pudleiner, P., Vereczkey, L. Study on the absorption of vinpocetine and apovincaminic acid. European Journal of Drug Metabolism and Pharmacokinetics 18, 317–321 (1993). https://doi.org/10.1007/BF03190179

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03190179

Keywords

Search

Navigation