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The influence of the route of administration on the bioavailability of an endogenous macromolecule: Chondroitin sulphate (CSA)

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Summary

The absorption of chondroitin sulphate (CSA) has been investigated in rabbits after the oral administration of a single dose of 100 mg of CSA per kg of body weight. The oral dose was administered as a lipid suspension or in enteric capsules.

No absorption of CSA could be demonstrated. Oral administration did not cause the release of a clearing factor into the bloodstream, a phenomenon that is known to occur in the presence of CSA. The concentration of this factor did not decrease after oral administration of CSA.

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Authors and Affiliations

  1. Laboratories P.O.S., Service de Recherches Biopharmaceutiques, F-68240, Kayserberg, France

    G. Andermann & M. Dietz

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  1. G. Andermann
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  2. M. Dietz
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Andermann, G., Dietz, M. The influence of the route of administration on the bioavailability of an endogenous macromolecule: Chondroitin sulphate (CSA). European Journal of Drug Metabolism and Pharmacokinetics 7, 11–16 (1982). https://doi.org/10.1007/BF03189537

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  • DOI: https://doi.org/10.1007/BF03189537

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