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The fate of total Flavanolic Oligomers (OFT) extracted from “Vitis vinifera L.” in the rat

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Summary

The elimination, metabolism and distribution of14C-Total Flavanolic Oligomers (OFT), vitamin P factors extracted from “Vitis vinifera”, has been described, in the rat, as a function of time. This study was carried out using [U-14C]-OFT, [A-14C]-OFT and [B-14C]-OFT.

After a single oral administration of 50 mg/kg [U-14C]-OFT, about 70% of the administered dose is eliminated in the first 24 hours: 6% of the dose is excreted as14CO2 in expired air, 19% is eliminated in urine and 45% in faeces. The major urinary metabolites are hippuric acid, ethylcatechol and m-hydroxyphenylpropionic acid. The major faecal metabolite is ethylcatechol. The major biliary metabolites are vanillic acid and m-hydroxyphenylpropionic acid.

The degradation of OFT is dependent on the activity of the microflora in the gut.

The distribution of radioactivity in rat tissues shows that there are two kinds of target tissues for OFT: connective tissues and tissues of the adrenal-thyroid-pituitary axis.

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Authors and Affiliations

  1. Unité de recherches sur les applications médicales et biologiques des isotopes radioactifs (U. 53), Institut National de la Santé et de la Recherche médicale, Bordeaux, France

    M. F. Harmand & P. Blanquet

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  1. M. F. Harmand
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  2. P. Blanquet
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Harmand, M.F., Blanquet, P. The fate of total Flavanolic Oligomers (OFT) extracted from “Vitis vinifera L.” in the rat. European Journal of Drug Metabolism and Pharmacokinetics 3, 15–30 (1978). https://doi.org/10.1007/BF03189365

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  • DOI: https://doi.org/10.1007/BF03189365

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