Skip to main content
SpringerLink
Log in

Mass spectrometric identification of urinary and plasma metabolites of 2-(6’-carboxyhexyl)-3-n-hexylcyclohexylamine, a new antiaggregating agent

  • Published:
European Journal of Drug Metabolism and Pharmacokinetics Aims and scope Submit manuscript

Summary

The compound IBI-P-05006, 2-(6’-carboxyhexyl)-3-n-hexylcyclohexylamine, is an antiaggregating agent under development. IBI-P-05006 is an in vitro inhibitor of platelet aggregation. The biotransformation of this compound has been studied in the dog and rat We present here a study on the metabolites of IBI-P-05006 found in dog and rat urine, and in dog plasma. Analyses were done by gas chromatography-mass spectrometry.

In dog urine 15 metabolites were identified. Some of them were also found in dog plasma and in rat urine. The unmetabolized drug was found only in plasma. 10 different hydroxylated metabolites were characterized. The hydroxyl groups were introduced in the hexyl chain in positions (ω-4, ω -3, ω -2, ω -1 and ω.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Similar content being viewed by others

References

  1. Valcavi U. (1987): Italian Pat Appl. 21055A/87.

  2. Valcavi U. (1989): Pat IT 1205183.

  3. Benfenati E., Fanelli R., Chiabrando C, Valcavi U., Bosone E., Farina P. (1988): Mass spectrometric identification of urinary and plasma metabolites of 9-hydroxy-19,20-bis-nor-prostanoic acid (Rosaprostol). Prostaglandins, 35, 665–684.

    Article  CAS  PubMed  Google Scholar 

  4. Raaijmakers J.G.A.M. (1977): System for the identification of novel prostaglandins. J. Chromatogr., 138, 355–372.

    Article  CAS  PubMed  Google Scholar 

  5. Budzikiewicz H., Djerassi C, Wilhams D.H. (1967): Mass Spectrometry of Organic Compounds. San Fransisco, Holden-Day, p. 471.

    Google Scholar 

  6. Kuhara T., Matsumoto I. (1974): Metabolism of branched medium chain length fatty acid. I. (ω-Oxidation of sodium dipropylacetate in rats. Biomed. Mass Spectrom, 1, 291–294.

    Article  CAS  PubMed  Google Scholar 

  7. Sun F.F., Taylor B.M. (1978): Metabolism of prostacyclin in rat. Biochemistry, 17, 4096–4101.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto Biochimico Italiano Giovanni Lorenzini, Milan, Italy

    R. Caponi & P. Farina

  2. Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, 1-20157, Milano, Italy

    E. Benfenati, R. Fanelli & E. Bosone

Authors
  1. E. Benfenati
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Fanelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Bosone
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Caponi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Farina
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Benfenati, E., Fanelli, R., Bosone, E. et al. Mass spectrometric identification of urinary and plasma metabolites of 2-(6’-carboxyhexyl)-3-n-hexylcyclohexylamine, a new antiaggregating agent. Eur. J. Drug Metab. Pharmacokinet. 17, 93–101 (1992). https://doi.org/10.1007/BF03188777

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03188777

Keywords

Search

Navigation