Zusammenfassung
Hintergrund
Neuere Verfahren ermöglichen die quantitative Erfassung der retinalen Nervenfaserschicht (RNFS) in vivo. Dies ist für die Frühdiagnostik der Glaukome von Bedeutung. Ziel der vorliegenden prospektiven Studie war der Vergleich der RNFS-Dicke in gesunden und glaukomkranken Augen anhand des Verfahrens der Scanning Laser Polarymetrie.
Patienten und Methoden
Die RNFS-Dicke von 43 normalen und 89 alterskorrelierten Augen wurde im Bereich einer um die Papille gelegenen Kreislinie anhand der Scanning Laser Polarymetrie (Nerve Fiber Analyzer [NFA]) gemessen. Die mediane RNFS-Dicke wurde für die superiore, inferiore, nasale und temporale Papillenumgebung getrennt bewertet.
In der superioren und inferioren Region zeigte sich eine statistisch signifikante Differenz zwischen der medianen RNFS-Dicke von normalen und glaukomkranken Augen (p<0,001). Eindeutige Grenzwerte ließen sich nicht festsetzen.
Schlussfolgerung
Die Quantifizierung der RNFS-Dicke ist ein Parameter für die Glaukomdiagnostik und stellt eine sinnvolle Ergänzung zu den konventionellen Diagnostika dar.
Summary
Background
Chronic open angle glaucoma is characterized by thinning of the retinal nerve fiber layer (RNFL). Scanning laser polarymetry allows the quantitative assessment of the RNFL and, therefore, has potential application for the early diagnosis of glaucoma. This study was performed to assess the RNFL thickness in healthy eyes versus eyes of patients with primary open angle glaucoma by scanning laser polarymetry.
Methods
In this prospective study 43 normal eyes and 89 glaucomatous eyes of age-matched patients were enrolled. With the Nerve Fiber Analyzer (NFA) RNFL thickness was measured on a circle around the optic nerve head. The RNFL was assessed for the total circumference of the optic nerve head as well as for the superior, inferior, nasal and temporal region.
Results
In the superior and inferior regions there was a statistically significant difference in the median RNFL thickness between normal and glaucomatous eyes (p<0.001). Cut-off points to differentiate normal from glaucomatous eyes could not be defined.
Conclusions
Quantitative assessment of RNFL thickness may provide a sensitive parameter for diagnosing and monitoring glaucomas and thus complement the diagnostic armamentarium.
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Herrn Prof. Freyler zum Geburtstag gewidmet.
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Klemm, M., Rumberger, E. & Richard, G. Quantifizierung der retinalen Nervenfaserschichtdicke — gemessen mit dem Nerve Fiber Analyzer (NFA) bei gesunden und glaukomkranken Augen. Spektrum Augeheilkd 14, 146–151 (2000). https://doi.org/10.1007/BF03163073
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DOI: https://doi.org/10.1007/BF03163073