Summary
1. In frog’s heart, on electrical stimulation, more acetylcholine per g./wt. is liberated from the lower half of the ventricle which is free from ganglion cells, than from the rest of the heart which contains ganglion cells. This suggests that acetylcholine mainly originates from the muscle cells.
2. The acetylcholine per g./wt. content of the ganglion free portion of the ventricle is greater than the rest of the heart which contains ganglia. This shows that acetylcholine is also contained in muscle cells besides nerve cells.
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References
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Singh, I., Singh, S.I. & Bhatnagar, O.P. The source of acetylcholine in the frog’s heart on direct electrical stimulation. Proc. Indian Acad. Sci. 51, 249–254 (1960). https://doi.org/10.1007/BF03050040
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DOI: https://doi.org/10.1007/BF03050040