Résumé
Les inhibiteurs de la pompe à protons, lansoprazole et oméprazole ont obtenu récemment l’indication du traitement symptomatique du reflux gastro-œsophagien. Il n’existe pas à ce jour d’étude comparative entre ces molécules aux dosages préconisés pour la prise en charge thérapeutique de cette pathologic.
Ce travail a pour objectif d’évaluer ces deux médicaments en termes d’efficacité et de tolérance. Quatre cent soixante deux patients ont été inclus, 233 recevant une dose quotidienne de 15 mg de lansoprazole et 229 une dose quotidienne de 10 mg d’oméprazole. Le pyrosis a disparu après 28 jours de traitement pour 90% des patients du groupe lansoprazole et 84% du groupe oméprazole (p=0.058). La tolérance a été excellente quelque soit le traitement administré.
Dans cet essai, les deux molécules ont fait la preuve de leur efficacité, les résultats montrant une tendance favorable au lansoprazole.
Summary
Symptomatic treatment of gastroesophageal reflux has recently been added to the indications of the proton pump inhibitors, lansoprazole and omeprazole. There are no comparative studies of these compounds in the literature at the recommended dosages. This comparison was carried out in the present study in terms of efficacy and safety. Four hundred sixty-two patients were included, i.e. 233 receiving 15mg of lansoprazole daily and 229 receiving 10 mg of omeprazole daily. After 28 days of therapy, pyrosis had disappeared in 90% of the lansoprazole group patients and in 84% of the the omeprazole group patients (p=0,058). The safety results were excellent whatever the treatment. In this trial, both compounds were found to be effective in this trial, although the results for lansoprazole seemed more favorable.
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Joubert-Collin, M., Vicari, F. & Perie, F. Efficacité et tolérance du lansoprazole 15 mg dans le traitement des symptômes du RGO — Comparaison à l’oméprazole 10 mg. Acta Endosc 28, 563–566 (1998). https://doi.org/10.1007/BF03036207
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DOI: https://doi.org/10.1007/BF03036207