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Embryology of the Little & Bagg

X-rayed mouse stock

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Summary

The morphology and development of the many defects in mice of the Little & Bagg X-rayed stock have been reinvestigated, in an attempt to resolve the conflicts in the findings of earlier investigators. The observation that blebs occur on pseudencephalic embryos is incompatible with Bonnevie’s hypothesis that they originate as cerebrospinal fluid in the myelencephalon; other observations support Plagens’ hypothesis that the blebs originate as mesenchymal intercellular fluid. No unitary gene action was found. Four pedigrees of causes were constructed covering, respectively, defects of the central nervous system, bleb-induced lesions and defects of the body wall, morphological defects of the hind limbs, and defects of the urogenital system; there were cross-correlations between defects in the first three pedigrees, but the underlying mechanisms were not identified.

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  1. T. C. Carter

    Present address: Western Chicken Limited, London Road, Devizes, Wiltshire, England

Authors and Affiliations

  1. Medical Research Council’s Radiobiological Research Unit, Harwell, Berkshire, England

    T. C. Carter

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Carter, T.C. Embryology of the Little & Bagg. J Genet 56, 401–435 (1959). https://doi.org/10.1007/BF02984794

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