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Exposure of females and pups of the levant vole to diethylstilbestrol (DES)-treated nesting material: Effect on the breeding capacity of the female offspring

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Abstract

Adult Levant vole (Microtus guentheri) females, which at the age of 1 or 4 days had been in direct contact for 2 h with filter paper impregnated with a suspension of diethylstilbestrol dipropionate (DES) in soybean oil (0.125 mg DES/cm2), or whose nursing mothers had been in similar contact with DES during that period, were found to be sterile in the overwhelming majority of cases. Females slightly older (5–6 days old) at the time of such contact with DES (direct, or through their nursing mothers) retained their fertility.

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References

  1. Burrows, H. (1949) Biological Actions of Sex Hormones. 2nd ed. Cambridge University Press, Cambridge, U.K.

    Google Scholar 

  2. Cargill, D.I., Meli, A., Giamaing, F. and Steinetz, B.C. (1969) Secretion of ethynilestradiol and its 3-cyclopentyl ether in the milk of lactating rats.Proc. Soc. exp. Biol. Med. 131: 1362–1365.

    PubMed  CAS  Google Scholar 

  3. Ennis, B.W. and Davies, J. (1982) Reproductive tract abnormalities in rats treated neonatally with diethylstilbestrol.Am. J. Anat. d164: 145–154.

    Article  Google Scholar 

  4. Forsberg, J.G. and Kalland, T. (1981) Neonatal estrogen treatment and epithelial abnormalities in the cervicovaginal epithelium of adult mice.Cancer Res.41: 721–734.

    PubMed  CAS  Google Scholar 

  5. German, A. (1980) Diethylstilbestrol as a reproduction inhibitor in the Levante vole.Phytoparasitica 8: 163–172.

    CAS  Google Scholar 

  6. German, A. (1981) Effect of diethylstilbestrol treatment of the Levant vole female during lactation on the reproduction of her female offspring.Phytoparasitica 9: 171–177.

    CAS  Google Scholar 

  7. German, A. (1982) Effect of external contact with diethylstilbestrol on the reproduction of female Levant voles.Phytoparasitica 10: 3–11.

    Article  CAS  Google Scholar 

  8. German, A. (1982) Contact action of diethylstilbestrol (DES)-impregnated paper strips on pregnant Levant voles: effect of alteration of DES concentration and of total strip area.Phytoparasitica 10: 111–112.

    Article  CAS  Google Scholar 

  9. German, A. (1982) Possible use of the contact chemosterilant effect of diethylstilbestrol (DES) for the suppression of pest rodent populations.Abstr. Third Int. Theriological Congr. (Helsinki, 1982). no. 92.

  10. Howard, W.E. and Marsh, R.E. (1969) Mestranol as a reproductive inhibitor in rats and voles.J. Wildl. Mgmt 33: 403–408.

    Article  Google Scholar 

  11. Leuenberger, U., Gauch, R., Mueller, U. and Hochstrasser, K. (1981) The passage of synthetic stilbestrols into cows milk.Mitt. Geb. Lebensmittelunters. Hyg. 72: 429–431.

    CAS  Google Scholar 

  12. Marsh, R.E. and Howard, W.E. (1982) Tracking powders as a rodent control technique.Abstr. Third Int. Theriological Congr. (Helsinki, 1982). no. 152.

  13. Newbold, R.R. and McLachlan, J.A. (1982) Vaginal adenosis and adenocarcinoma in mice exposed prenatally or neonatally to diethylstilbestrol.Cancer Res.42: 2003–2011.

    PubMed  CAS  Google Scholar 

  14. Planpinger, L. (1981) Morphological effects of diethylstilbestrol on neonatal mouse uterus and vagina.Cancer Res.41: 4667–4677.

    Google Scholar 

  15. Walker, S.M. and Stanley, A.J. (1941) Effect of diethylstilbestrol dipropionate on mammary development and lactation.Proc. Soc. exp. Biol. Med. 48: 50–53.

    CAS  Google Scholar 

  16. Weichert, C.K. and Kerrigan, S. (1942) Effects of estrogens upon the young of injected lactating rats.Endocrinology 30: 741–752.

    Article  CAS  Google Scholar 

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German, A., Rubina, M. Exposure of females and pups of the levant vole to diethylstilbestrol (DES)-treated nesting material: Effect on the breeding capacity of the female offspring. Phytoparasitica 12, 65–69 (1984). https://doi.org/10.1007/BF02980799

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