Skip to main content
SpringerLink
Log in

Triterpenoids fromAcanthopanax koreanum root and their inhibitory activities on NFAT transcription

  • Research Articles
  • Articles
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root ofAcanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-0-[α-L-rhamnopyranosyl(1→4)-p-D-glucopyrano-syl(1→6)]-β-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50:12.65 μ.M).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bensky, D. and Gamble, A., Materia medica. Eastland press, Washington, pp. 161–162 (1986).

    Google Scholar 

  • Cai, X. F., Shen, G. H., Nguyen, T. D., Kang, O. H., Lee, Y. M., Lee, J. J., and Kim, Y. H., Inhibitory effect of kaurane type diterpenoids fromAcanthopanax koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells.Arch. Pharm. Res., 26, 731–734 (2003a).

    Article  CAS  Google Scholar 

  • Cai, X. F., Shen, G. H., Nguyen, T. D., Kang, O. H., Kim, J. A., Lee, Y. M., Lee, J. J., and Kim, Y. H., Inhibitory effect of TNF-α and IL-8 secretion by pimarane-type diterpenoids fromAcanthopanax koreanum.Chem. Pharm. Bull., 51, 605–607 (2003b).

    Article  CAS  Google Scholar 

  • Chang, S. Y., Yook, C. S., and Nohara, T., Two new lupanetriterpene glycosides from leaves of Acanthopanax koreanum.Chem. Pharm. Bull., 46, 163–165 (1998).

    CAS  Google Scholar 

  • Han, S. B., Park, S. K., Ahn, H. J., Yoon, Y. D., Kim, Y. H., Lee, J. J., Lee, K. H., Moon, J. S., Kim, H. C., and Kim, H. M., Characterization of B cell membrane receptors of polysaccharide isolated from the root of Acanthopanax koreanum.Int. Immunopharmacol., 3, 683–691 (2003).

    Article  PubMed  CAS  Google Scholar 

  • Jain, J., Loh, C., and Rao, A., Transcriptional regulation of the IL-2 gene.Curr. Opin. Immunol., 7, 333–342 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Jeong, T. S., Hwang, E. I., Lee, H. B., Lee, E. S., Kim, Y. K., Min, B. S., Bae, K. H., Bok, S. H., and Kim, S. U., Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida.Planta Med., 65, 261–263 (1999).

    Article  PubMed  CAS  Google Scholar 

  • Kim, J. Y. and Yang, K. S., Screening of antioxidant activity ofAcanthopanax species in vitro.Yakhak Hoeji, 47, 361–364 (2003).

    CAS  Google Scholar 

  • Kim, Y. H., Chung, B. S., and Sankawa, U., Pimaradiene diterpenes from Acanthopanax koreanum.J. Nat. Prod., 51, 1080–1083 (1988).

    Article  CAS  Google Scholar 

  • Kim, Y. H., Ryu, J. H., and Chung, B. S., Diterpene glycoside from Acanthopanax koreanum.Kor. J. Pharmacogn., 21, 49–51 (1990).

    CAS  Google Scholar 

  • Lee, I. S., Dang, T. L. H., Lee, M. S., Kim, J. W., Na, D. S., and Kim, Y. H., NFAT transcription factor inhibitory constituents from Cnidium officinale.Nat. Prod. Sci., 8, 94–96 (2002).

    CAS  Google Scholar 

  • Lee, I. S., Lee, H. K., Nguyen, T. D., Lee, M. S., Kim, J. W., Na, D. S., and Kim, Y. H., Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis.Planta Med., 69, 63–64 (2003).

    Article  PubMed  CAS  Google Scholar 

  • Lee, Y. N.,Flora of Korea. Kyohaksa, Seoul, p. 544 (1996).

    Google Scholar 

  • Min, B. S., Kim, Y. H., Lee, S. M., Jung, J. H., Lee, S. J., Na, M. K., Lee, C. O., Lee, J. P., and Bae, K. H., Cytotoxic triterpenes from Crataegus pinnatifida.Arch. Pharm. Res., 23, 155–158 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Shin, K. H. and Lee, S., The chemistry of secondary products fromAcanthopanax species and their pharmacological activities.Nat. Prod. Sci., 8, 111–126 (2002).

    CAS  Google Scholar 

  • Sung, T. V., Steglich, W., and Adam, G., Triterpene glycosides from Schefflera octophylla.Phytochem., 30, 2349–2356 (1991).

    Article  CAS  Google Scholar 

  • Ty, P. D., Lischewski, M., Phiet, H. V., Preiss, A., Sung, T. V., Schmidt, J., and Adam, G., Two triterpenoid carboxylic acids from Acanthopanax trifoliatus.Phytochem., 23, 2889–2891 (1984).

    Article  CAS  Google Scholar 

  • Yang, T. T., Sinai, P., Kitts, P. A., and Kain, S. R., Quantification of gene expression with a secreted alkaline phosphatase reporter system.Biotechniques, 23, 1110–1114 (1997).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Pharmacy, Chungnam National University, 305-764, Daejeon, Korea

    Xing Fu Cai, Im Seon Lee, Guanghai Shen, Nguyen Tien Dat, Jung Joon Lee & Young Ho Kim

Authors
  1. Xing Fu Cai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Im Seon Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Guanghai Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nguyen Tien Dat
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jung Joon Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Young Ho Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Young Ho Kim.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cai, X.F., Lee, I.S., Shen, G. et al. Triterpenoids fromAcanthopanax koreanum root and their inhibitory activities on NFAT transcription. Arch Pharm Res 27, 825–828 (2004). https://doi.org/10.1007/BF02980173

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02980173

Key words

Search

Navigation