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Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases

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Abstract

Ketorolac tromethamine gel (KT gel) and ketorolac tromethamine gel containing genipin (KTG gel) were prepared and their therapeutic effects on periodontitis were evaluated. The skin permeation rate of ketorolac from the KT gel and KTG gel was 5.75±0.53 and 5.82 ± 0.74 (ig/cm2/ h, respectively. The skin permeation rate of genipin from the KTG gel was 10.13 ± 1.47 [μl cm2/h. The tensile strength of the KTG gel was larger than the KT gel. After 4 weeks, the periodontal pocket depth of the KTG gel group (3.22 ± 0.20 mm) significantly decreased compared with the non-treated group (4.50 ± 0.25 mm) and the KT group (3.84 ± 00.26 mm). The KTG gel did not induce separation of the stratum corneum and subcutaneous tissue, and the collagen layers of the corium were closer, more fibrous, and showed longer connections than in the other groups. The KTG gel appears to be effective against gingivitis in the periodontal pocket through its increased anti-inflammatory activity and the crosslinking of genipin with the biological tissue.

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Authors and Affiliations

  1. Department of Dental Hygiene, Chonbuk Science College, 580-712, Jeongeup, Korea

    Mi -Jeong Kim

  2. Pharmaceutical Engineering Department, Konyang University, 320-711, Nonsan, Korea

    Young-ll Kim

  3. Department of Physical Therapy, Dongshin University, 520-714, Naju, Korea

    Tae -Youl Kim

  4. School of Dentistry, Dental Research Institute and Second Stage of BK21, Chonam National University, 501-746, Gwangju, Korea

    Kyu -Ho Yang

  5. College of Pharmacy, Chonnam National University, 500-757, Gwangju, Korea

    Sang -Chul Shin

  6. College of Pharmacy, Woosuk University, 565-701, Wanju, Korea

    Jeon -Heon Yang, Mi -Young Yun & Dae -Keun Kim

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  1. Jeon -Heon Yang
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  2. Mi -Young Yun
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  4. Mi -Jeong Kim
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  5. Young-ll Kim
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  7. Kyu -Ho Yang
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  8. Sang -Chul Shin
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Correspondence to Sang -Chul Shin.

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Yang, J.H., Yun, M.Y., Kim, D.K. et al. Preparation and evaluation of ketorolac tromethamine gel containing genipin for periodontal diseases. Arch Pharm Res 30, 871–875 (2007). https://doi.org/10.1007/BF02978839

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  • DOI: https://doi.org/10.1007/BF02978839

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