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Trichodermamide A and aspergillazine A, two cytotoxic modified dipeptides from a marine-derived fungusSpicaria elegans

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Abstract

Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungusSpicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds1 and2 from the fungusSpicaria elegans and their cytotoxic effect.

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Correspondence to Qian-Qun Gu or Wei-Ming Zhu.

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Liu, R., Gu, QQ., Zhu, WM. et al. Trichodermamide A and aspergillazine A, two cytotoxic modified dipeptides from a marine-derived fungusSpicaria elegans . Arch Pharm Res 28, 1042–1046 (2005). https://doi.org/10.1007/BF02977399

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  • DOI: https://doi.org/10.1007/BF02977399

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