Abstract
Thein vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots ofAngelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) fromA. gigas have anti-tumor activities.
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Ahn, K.-S., Sim, W.-S., and Kim, I.-H., Decursin, A cytotoxic agent and protein kinase C activator from the root ofAngelica gigas.Planta Med., 62, 7–9 (1996).
Ahn, K.-S., Sim, W.-S., Lee, I.-K., Seu, Y.-B., and Kim, I.-H., Decursinol angelate, A cytotoxic and protein kinase C activating agent from the root ofAngelica gigas.Planta Med., 63, 360–361 (1997).
Chi, H.-J., and Kim, H. S., Studies on the essential oils of plants ofAngelica genus in Korea (I). Essential oils ofAngelicae gigantis radix.Kor. J. Pharmacogn., 19, 239–247 (1988).
Chi, H.-J., Studies on the components of Umbelliferous plants in Korea (IV).Yakhak Hoeji, 13, 47–50 (1969).
Choi, Y. E., Ahn, H., and Ryu, J.-H., Polyacetylenes fromAngelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages.Biol. Pharm. Bull., 23, 884–886 (2000).
Han, D. S., Pharmacognosy, 4th ed., Dongmyongsa Press, Seoul, Korea, pp. 201–202 (1992).
Jung, D. J., Porzel, A., and Huneck, S., Gigasol and other coumarins fromAngelica gigas.Phytochemistry, 30, 710–712 (1991).
Kang, K. S., Ryu, S. H., and Ahn, B. Z., Antineoplastic natural products and the analogues IV. Aurapten, the cytotoxic coumarin fromPoncirus trifoliata against L1210 cells.Arch. Pharm. Res., 8, 187–190 (1985).
Kang, S. Y., Lee, K. Y., Sung, S. H., Park, M. J., and Kim, Y. C., Coumarins isolated fromAngelica gigas inhibit acetyl cholinesterase: Structure-activity relationships.J. Nat. Prod., 64, 683–685 (2001).
Kim, H.-S., Park, J.-S., Park, H.-J., and Chi, H.-J., A study of the effects of the root components ofAngelica gigas Nakai on voluntary activity in mice.Kor. J. Pharmacogn., 11, 11–14 (1980).
Konoshima, M., Chi, H.-J., and Hata, K., Coumarins from the root ofAngelica gigas Nakai.Chem. Pharm. Bull., 16, 1139–1140 (1968).
Lee, S., Kang, S. S., and Shin, K. H., Coumarins and a pyrimidine fromAngelica gigas roots.Nat. Prod. Sci., 8, 58–61 (2002).
Pachaly, P., Treitner, A., and Sin, K. S., Neue Cumaringlykoside ausAngelica gigas.Pharmazie, 51, 57–61 (1996).
Ryu, K. S., Hong, N. D., Kim, N. J., and Kong, Y. Y., Studies on the coumarin constituents of the root ofAngelica gigas Nakai. Isolation of decursinol angelate and assay of decursin angelate and decursin.Kor. J. Pharmacogn., 21, 64–68 (1990).
Shin, K. H., Han, J. M., and Lee, I. R., Effect of the constituents ofAngelicae gigantis radix on hepatic drug metabolizing enzymes.Kor. J. Pharmacogn., 27, 323–327 (1996).
Yook, C. S., Coloured medicinal plants of Korea. Academy Book, Seoul, Korea, p. 390 (1990).
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Lee, S., Lee, Y.S., Jung, S.H. et al. Anti-tumor activities of decursinol angelate and decursin fromAngelica gigas . Arch Pharm Res 26, 727–730 (2003). https://doi.org/10.1007/BF02976682
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DOI: https://doi.org/10.1007/BF02976682