Abstract
5,8-Quinazolinediones modified at positions6 and7 were synthesized and tested forin vitro antifungal activities againstCandida species andAspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).
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Ryu, C.K., Shim, J.Y., Yi, Y.J. et al. Synthesis and antifungal activity of 5,8-quinazolinedione derivatives modified at positions 6 and 7. Arch Pharm Res 27, 990–996 (2004). https://doi.org/10.1007/BF02975419
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DOI: https://doi.org/10.1007/BF02975419